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Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry

Overview of attention for article published in BMC Cancer, December 2015
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Title
Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry
Published in
BMC Cancer, December 2015
DOI 10.1186/s12885-015-1995-1
Pubmed ID
Authors

Ana Maria Passos-Castilho, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Luciana Kikuchi, Aline Lopes Chagas, Michele Soares Gomes-Gouvêa, Fernanda Malta, Ana Catharina de Seixas-Santos Nastri, João Renato Rebello Pinho, Flair José Carrilho, Celso Francisco Hernandes Granato

Abstract

Chronic hepatitis B (CHB) virus infection is a major cause of hepatocellular carcinoma (HCC), as late diagnosis is the main factor for the poor survival of patients. There is an urgent need for accurate biomarkers for early diagnosis of HCC. The aim of the study was to explore the serum lipidome profiles of hepatitis B-related HCC to identify potential diagnostic biomarkers. An ultraperformance liquid chromatography mass spectrometry (UPLC-MS) lipidomic method was used to characterize serum profiles from HCC (n = 32), liver cirrhosis (LC) (n = 30), CHB (n = 25), and healthy subjects (n = 34). Patients were diagnosed by clinical laboratory and imaging evidence and all presented with CHB while healthy controls had normal liver function and no infectious diseases. The UPLC-MS-based serum lipidomic profile provided more accurate diagnosis for LC patients than conventional alpha-fetoprotein (AFP) detection. HCC patients were discriminated from LC with 78 % sensitivity and 64 % specificity. In comparison, AFP showed sensitivity and specificity of 38 % and 93 %, respectively. HCC was differentiated from CHB with 100 % sensitivity and specificity using the UPLC-MS approach. Identified lipids comprised glycerophosphocolines, glycerophosphoserines and glycerophosphoinositols. UPLC-MS lipid profiling proved to be an efficient and convenient tool for diagnosis and screening of HCC in a high-risk population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 21%
Researcher 8 17%
Student > Ph. D. Student 8 17%
Other 5 10%
Student > Bachelor 3 6%
Other 6 13%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 40%
Medicine and Dentistry 9 19%
Agricultural and Biological Sciences 3 6%
Engineering 2 4%
Immunology and Microbiology 2 4%
Other 3 6%
Unknown 10 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2015.
All research outputs
#21,264,673
of 23,881,329 outputs
Outputs from BMC Cancer
#6,689
of 8,483 outputs
Outputs of similar age
#334,243
of 393,340 outputs
Outputs of similar age from BMC Cancer
#148
of 181 outputs
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