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IL-17 promoted the inhibition of medulloblastoma in mice by splenocyte injection

Overview of attention for article published in European Journal of Medical Research, December 2015
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Title
IL-17 promoted the inhibition of medulloblastoma in mice by splenocyte injection
Published in
European Journal of Medical Research, December 2015
DOI 10.1186/s40001-015-0191-8
Pubmed ID
Authors

Ping Zhou, Qilin Zhang, Yao Zhao, Hongying Sha, Xiaoyun Cao, Yongfei Wang

Abstract

Interleukin 17 (IL-17) is a proinflammatory cytokine produced by a new subset of activated CD4+ T cells, Th17 cells. We previously showed that increased Th17 cell populations were presented in human medulloblastoma-infiltrating T cells and peripheral blood. In this study, we attempted to address the possible role of Th17 cells in the biologic activity of IL-17 for tumor control. We grafted fresh surgically obtained medulloblastoma into syngeneic athymic nude/nude mice. We intrapertonially injected splenocyte and murine IL-17 in mice on the second day. The tumor volume and the life spans of the mice were measured. Meanwhile, the IL-17, IL-6, IL-23, Ccl2, Ccl20 and IFN-gamma expression in the tumors was also examined by real-time PCR, Western blot and enzyme-linked immunosorbent assay. We found that medulloblastoma growth in IL-17-injected mice was significantly inhibited compared to the non-IL-17 treated mice. In contrast to the IL-17 antitumor activity observed in mice injected with splenocytes, we observed that IFN-gamma, IL-6, IL-23, Ccl2, and Ccl20 proteins were significantly increased in tumor tissues of mice injected with IL-17. These experiments suggest that IL-17 may promote splenocyte antitumor activity in medulloblastoma. We postulate that IL-17's antitumor activity may be related to the increased protein levels of IFN-gamma, IL-6, IL-23, Ccl2, and Ccl20.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 36%
Student > Bachelor 4 29%
Other 1 7%
Student > Doctoral Student 1 7%
Researcher 1 7%
Other 0 0%
Unknown 2 14%
Readers by discipline Count As %
Medicine and Dentistry 3 21%
Biochemistry, Genetics and Molecular Biology 2 14%
Agricultural and Biological Sciences 2 14%
Nursing and Health Professions 1 7%
Neuroscience 1 7%
Other 1 7%
Unknown 4 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2015.
All research outputs
#5,813,052
of 6,797,067 outputs
Outputs from European Journal of Medical Research
#142
of 190 outputs
Outputs of similar age
#237,655
of 293,351 outputs
Outputs of similar age from European Journal of Medical Research
#6
of 7 outputs
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