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Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa

Overview of attention for article published in BMC Research Notes, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
48 Mendeley
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Title
Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa
Published in
BMC Research Notes, December 2015
DOI 10.1186/s13104-015-1686-7
Pubmed ID
Authors

Markus Schosserer, Rita Reynoso, Verena Wally, Bogdan Jug, Viktoria Kantner, Sylvia Weilner, Ivana Buric, Johannes Grillari, Johann W. Bauer, Regina Grillari-Voglauer

Abstract

Regenerative medicine is strictly dependent on stem cells as a source for a high diversity of somatic cells. However, the isolation of such from individuals suffering from severe genetic skin blistering diseases like epidermolysis bullosa (EB) is often associated with further organ damage. Stem cells were isolated from 112 urine samples from 21 different healthy donors, as well as from 33 urine samples from 25 donors with EB. The cultivation of these cells was optimized by testing different media formulations and pre-coating of culture vessels with collagen. The identity of cells was confirmed by testing marker expression, differentiation potential and immune-modulatory properties. We provide here an optimized protocol for the reproducible isolation of mesenchymal stem cells from urine, even from small volumes as obtained from patients with EB. Furthermore, we offer a basic characterization of those urine-derived stem cells (USCs) from healthy donors, as well as from patients with EB, and demonstrate their potential to differentiate into chondrocytes, osteoblasts and adipocytes, as well as their immune-modulatory properties. Thus, USCs provide a novel and non-invasive source of stem cells, which might be applied for gene-therapeutic approaches to improve medical conditions of patients with EB.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Student > Ph. D. Student 7 15%
Student > Master 6 13%
Professor > Associate Professor 4 8%
Other 4 8%
Other 9 19%
Unknown 9 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 23%
Biochemistry, Genetics and Molecular Biology 11 23%
Medicine and Dentistry 6 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Immunology and Microbiology 1 2%
Other 6 13%
Unknown 11 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2016.
All research outputs
#554,039
of 7,474,500 outputs
Outputs from BMC Research Notes
#109
of 1,887 outputs
Outputs of similar age
#30,413
of 302,618 outputs
Outputs of similar age from BMC Research Notes
#8
of 150 outputs
Altmetric has tracked 7,474,500 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,887 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,618 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 150 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.