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Brain mediators of systemic oxidative stress on perceptual impairments in Parkinson’s disease

Overview of attention for article published in Journal of Translational Medicine, December 2015
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Title
Brain mediators of systemic oxidative stress on perceptual impairments in Parkinson’s disease
Published in
Journal of Translational Medicine, December 2015
DOI 10.1186/s12967-015-0749-9
Pubmed ID
Authors

Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu, Ching-Po Lin

Abstract

Parkinson's disease (PD) is well documented to be associated with elevated systemic oxidative stress and perceptual impairments. Furthermore, the striatum and extrastriatal cortical areas, which are involved in the coordination of perceptual functions, are impaired at an early stage of the disease. However, the possible pathophysiology involved in perceptual impairments remains unclear. This raises the possibility that structural abnormalities might mediate the relationship between oxidative stress and perceptual impairments. We explored the differences between 27 patients with PD and 25 healthy controls in terms of serum oxidative stress, perceptual functions, and regional gray matter. A single-level three-variable mediation model was used to investigate the possible relationships between serum oxidative stress, regional gray matter volume, and different domains of perceptual functioning. The results demonstrate that increased serum oxidative stress (as indicated by thiobarbituric acid reactive substances) was associated with declined perceptual functioning in PD patients. We further explored significant gray matter volume reductions in the bilateral temporal gyri (middle temporal gyrus and fusiform gyrus), bilateral frontal gyri, limbic lobe (hippocampus and uncus), left inferior parietal lobule, right caudate nucleus, and insula in PD. Further mediation analysis showed that gray matter volumes in the middle temporal gyrus, inferior parietal lobule, hippocampus, and insula served as brain mediators between elevated serum oxidative stress and perceptual impairments. These results suggest that higher oxidative stress levels adversely impact perceptual functions by causing temporal and mesolimbic abnormalities.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 25%
Student > Bachelor 4 20%
Student > Postgraduate 3 15%
Student > Ph. D. Student 2 10%
Professor 1 5%
Other 3 15%
Unknown 2 10%
Readers by discipline Count As %
Neuroscience 4 20%
Medicine and Dentistry 4 20%
Agricultural and Biological Sciences 2 10%
Psychology 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 3 15%
Unknown 4 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2015.
All research outputs
#3,295,613
of 6,803,403 outputs
Outputs from Journal of Translational Medicine
#912
of 1,637 outputs
Outputs of similar age
#149,771
of 294,389 outputs
Outputs of similar age from Journal of Translational Medicine
#52
of 83 outputs
Altmetric has tracked 6,803,403 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,637 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,389 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.