Title |
Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients
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Published in |
BMC Neurology, September 2018
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DOI | 10.1186/s12883-018-1165-6 |
Pubmed ID | |
Authors |
Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö, Björn Hammar |
Abstract |
To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration. Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer. The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46). The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients. |
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
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Other | 3 | 12% |
Student > Master | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Librarian | 1 | 4% |
Other | 6 | 24% |
Unknown | 7 | 28% |
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Neuroscience | 2 | 8% |
Unspecified | 1 | 4% |
Energy | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 32% |