Title |
De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes
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Published in |
BMC Genomics, December 2011
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DOI | 10.1186/1471-2164-12-600 |
Pubmed ID | |
Authors |
Roberto A Barrero, Brett Chapman, Yanfang Yang, Paula Moolhuijzen, Gabriel Keeble-Gagnère, Nan Zhang, Qi Tang, Matthew I Bellgard, Deyou Qiu |
Abstract |
Euphorbia fischeriana is an important medicinal plant found in Northeast China. The plant roots contain many medicinal compounds including 12-deoxyphorbol-13-acetate, commonly known as prostratin that is a phorbol ester from the tigliane diterpene series. Prostratin is a protein kinase C activator and is effective in the treatment of Human Immunodeficiency Virus (HIV) by acting as a latent HIV activator. Latent HIV is currently the biggest limitation for viral eradication. The aim of this study was to sequence, assemble and annotate the E. fischeriana transcriptome to better understand the potential biochemical pathways leading to the synthesis of prostratin and other related diterpene compounds. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 2 | 3% |
Brazil | 1 | 1% |
Germany | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 63 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 28% |
Researcher | 15 | 22% |
Student > Doctoral Student | 6 | 9% |
Student > Master | 6 | 9% |
Other | 5 | 7% |
Other | 10 | 14% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 40 | 58% |
Chemistry | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Computer Science | 2 | 3% |
Economics, Econometrics and Finance | 2 | 3% |
Other | 3 | 4% |
Unknown | 14 | 20% |