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Protective effect of probiotics on Salmonella infectivity assessed with combined in vitro gut fermentation-cellular models

Overview of attention for article published in BMC Microbiology, December 2011
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Mentioned by

twitter
5 tweeters

Citations

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34 Dimensions

Readers on

mendeley
98 Mendeley
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Title
Protective effect of probiotics on Salmonella infectivity assessed with combined in vitro gut fermentation-cellular models
Published in
BMC Microbiology, December 2011
DOI 10.1186/1471-2180-11-264
Pubmed ID
Authors

Annina Zihler, Mélanie Gagnon, Christophe Chassard, Christophe Lacroix

Abstract

Accurate assessment of probiotics with targeted anti-Salmonella activity requires suitable models accounting for both, microbe-microbe and host-microbe interactions in gut environments. Here we report the combination of two original in vitro intestinal models closely mimicking the complex in vivo conditions of the large intestine. Effluents from continuous in vitro three-stage fermentation colonic models of Salmonella Typhimurium infection inoculated with immobilized child microbiota and Salmonella were directly applied to confluent mucus-secreting HT29-MTX cell layers. The effects of Salmonella, addition of two bacteriocinogenic strains, Bifidobacterium thermophilum RBL67 (thermophilicin B67) and Escherichia coli L1000 (microcin B17), and inulin were tested on Salmonella growth and interactions with epithelial cell layers. Salmonella adhesion and invasion were investigated and epithelial integrity assessed by transepithelial electrical resistance (TER) measurements and confocal microscopy observation. Data from complex effluents were compared with pure Salmonella cultures.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Italy 1 1%
Argentina 1 1%
Switzerland 1 1%
Unknown 94 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 19%
Researcher 16 16%
Student > Doctoral Student 11 11%
Student > Master 10 10%
Student > Bachelor 9 9%
Other 21 21%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 40%
Biochemistry, Genetics and Molecular Biology 13 13%
Medicine and Dentistry 12 12%
Immunology and Microbiology 8 8%
Nursing and Health Professions 3 3%
Other 11 11%
Unknown 12 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2011.
All research outputs
#12,267,615
of 21,331,034 outputs
Outputs from BMC Microbiology
#1,127
of 3,043 outputs
Outputs of similar age
#142,550
of 248,730 outputs
Outputs of similar age from BMC Microbiology
#68
of 114 outputs
Altmetric has tracked 21,331,034 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,043 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,730 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.