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Derivation of consensus inactivation status for X-linked genes from genome-wide studies

Overview of attention for article published in Biology of Sex Differences, December 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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11 X users
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1 Facebook page
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1 Wikipedia page

Citations

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132 Mendeley
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Title
Derivation of consensus inactivation status for X-linked genes from genome-wide studies
Published in
Biology of Sex Differences, December 2015
DOI 10.1186/s13293-015-0053-7
Pubmed ID
Authors

Bradley P. Balaton, Allison M. Cotton, Carolyn J. Brown

Abstract

X chromosome inactivation is the epigenetic silencing of the majority of the genes on one of the X chromosomes in XX therian mammals. In humans, approximately 15 % of genes consistently escape from this inactivation and another 15 % of genes vary between individuals or tissues in whether they are subject to, or escape from, inactivation. Multiple studies have provided inactivation status calls for a large subset of the genes on the X chromosome; however, these studies vary in which genes they were able to make calls for and in some cases which call they give a specific gene. This analysis aggregated three published studies that have examined X chromosome inactivation status of genes across the X chromosome, generating consensus calls and identifying discordancies. The impact of expression level and chromosomal location on X chromosome inactivation status was also assessed. Overall, we assigned a consensus XCI status 639 genes, including 78 % of protein-coding genes expressed outside of the testes, with a lower frequency for non-coding RNA and testis-specific genes. Study-specific discordancies suggest that there may be instability of XCI during cell culture and also highlight study-specific variations in call type. We observe an enrichment of discordant genes at boundaries between genes subject to and escaping from inactivation. This study has compiled a comprehensive list of X-chromosome inactivation statuses for genes and also discovered some biases which will help guide future studies examining X-chromosome inactivation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 131 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 24%
Student > Bachelor 23 17%
Researcher 15 11%
Student > Master 11 8%
Student > Postgraduate 7 5%
Other 14 11%
Unknown 30 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 50 38%
Agricultural and Biological Sciences 22 17%
Medicine and Dentistry 11 8%
Immunology and Microbiology 4 3%
Neuroscience 4 3%
Other 9 7%
Unknown 32 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2023.
All research outputs
#3,303,007
of 25,540,105 outputs
Outputs from Biology of Sex Differences
#133
of 587 outputs
Outputs of similar age
#52,919
of 400,566 outputs
Outputs of similar age from Biology of Sex Differences
#2
of 16 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 587 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,566 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.