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Limb remote ischemic postconditioning protects cerebral ischemia from injury associated with expression of HIF-1α in rats

Overview of attention for article published in BMC Neuroscience, December 2015
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Title
Limb remote ischemic postconditioning protects cerebral ischemia from injury associated with expression of HIF-1α in rats
Published in
BMC Neuroscience, December 2015
DOI 10.1186/s12868-015-0235-6
Pubmed ID
Authors

Yonghua Zong, Ling Jiang, Mingxiao Zhang, Fangfang Zhou, Wenqian Qi, Shuai Li, Huijun Yang, Yu Zou, Qingjie Xia, Xue Zhou, Xiaosong Hu, Tinghua Wang

Abstract

Limb remote ischemic postconditioning (LRIP) can ameliorate cerebral ischemia-reperfusion injury (IRI), while the underlying mechanism remains elusive. Hypoxia-inducible factor 1α (HIF-1α) is an important transcription factor during cerebral ischemia damage. However, whether the neuroprotective effect of LRIP could be associated with HIF-1α is somewhat unclear. Here we tested the hypothesis that Limb remote ischemic postconditioning (LRIP) protecting brain from injury in middle cerebral artery occlusion (MCAO) rat model was associated with HIF-1α expression. LRIP was conducted with 3 cycles of 10 min occlusion/10 min reperfusion at the beginning of reperfusion. The analysis of neurobehavioral function and triphenyltetrazolium chloride (TTC) staining showed the neurological deficit, brain infarct and cerebral edema, caused by ischemia-reperfusion injury (IRI), were dramatically ameliorated in LRIP administrated animals. Meanwhile, the result of Q-PCR and western blot revealed that the overexpression of HIF-1α induced by IRI could be notably suppressed by LRIP treatment. LRIP exhibits a protective effect against cerebral ischemia/reperfusion and the possible mechanism is associated with the suppression of HIF-1α in stroke rats.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Researcher 4 16%
Student > Master 4 16%
Student > Bachelor 3 12%
Student > Doctoral Student 2 8%
Other 4 16%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 8 32%
Agricultural and Biological Sciences 7 28%
Biochemistry, Genetics and Molecular Biology 2 8%
Neuroscience 2 8%
Computer Science 1 4%
Other 2 8%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2015.
All research outputs
#5,908,353
of 6,896,042 outputs
Outputs from BMC Neuroscience
#634
of 764 outputs
Outputs of similar age
#244,558
of 300,796 outputs
Outputs of similar age from BMC Neuroscience
#33
of 37 outputs
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