Title |
MicroRNA-mediated gene regulation plays a minor role in the transcriptomic plasticity of cold-acclimated Zebrafish brain tissue
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Published in |
BMC Genomics, December 2011
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DOI | 10.1186/1471-2164-12-605 |
Pubmed ID | |
Authors |
Ruolin Yang, Zhonghua Dai, Shue Chen, Liangbiao Chen |
Abstract |
MicroRNAs (miRNAs) play important roles in regulating the expression of protein-coding genes by directing the degradation and/or repression of the translation of gene transcripts. Growing evidence shows that miRNAs are indispensable player in organismal development with its regulatory role in the growth and differentiation of cell lineages. However, the roles of miRNA-mediated regulation in environmental adaptation of organisms are largely unknown. To examine this potential regulatory capability, we characterized microRNAomes from the brain of zebrafish raised under normal (28 °C) and cold-acclimated (10 °C, 10 days) conditions using Solexa sequencing. We then examined the expression pattern of the protein-coding genes under these two conditions with Affymetrix Zebrafish Genome Array profiling. The potential roles of the microRNAome in the transcriptomic cold regulation in the zebrafish brain were investigated by various statistical analyses. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
Portugal | 1 | 2% |
France | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 26% |
Researcher | 11 | 23% |
Student > Master | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 3 | 6% |
Other | 7 | 15% |
Unknown | 3 | 6% |
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Biochemistry, Genetics and Molecular Biology | 11 | 23% |
Environmental Science | 3 | 6% |
Medicine and Dentistry | 2 | 4% |
Psychology | 1 | 2% |
Other | 0 | 0% |
Unknown | 4 | 9% |