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Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot

Overview of attention for article published in BMC Complementary and Alternative Medicine, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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7 tweeters
facebook
2 Facebook pages

Citations

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34 Dimensions

Readers on

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72 Mendeley
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Title
Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot
Published in
BMC Complementary and Alternative Medicine, January 2016
DOI 10.1186/s12906-015-0973-0
Pubmed ID
Authors

Joicy Cortez de Sá, Fernando Almeida-Souza, Renata Mondêgo-Oliveira, Iara dos Santos da Silva Oliveira, Lyah Lamarck, Isadora de Fátima Braga Magalhães, Aarão Filipe Ataídes-Lima, Higor da Silva Ferreira, Ana Lucia Abreu-Silva

Abstract

Leishmaniasis includes a wide complex of diseases that affect humans and other mammals, and can range from a mild cutaneous form to a severe visceral type. The safety of the standard treatment using pentavalent antimony is a concern due to its toxic effects. The search for alternative, effective and less toxic treatments has led to the testing of natural products. The present study aimed to evaluate the cytotoxic, leishmanicidal and healing potential of Arrabidaea chica. The crude ethanolic extract, as well as the chloroform, methanol and ethyl acetate fractions of A. chica were prepared and phytochemical analysis was performed. Cytotoxic evaluation was carried out through MTT colorimetric assay, and the 50 % cellular cytotoxicity was determined. After that, the effect of the extract and fractions against Leishmania amazonensis promastigotes, at intervals of 24, 48 and 72 h, was analyzed, and 50 % inhibitory concentration was determined. The healing effect of the plant was also tested in surgical lesions in Swiss mice skin. Phytochemical screening showed that the crude extracts contained flavonoids, tannins, anthocyanidins and chalcones. The leishmanicidal potential of A. chica produced satisfactory results in concentrations of between 60 and 155.9 μg/mL. Cytotoxic assay revealed a 50 % reduction in viable cells at a concentration of 189.9 μg/mL. The healing results indicated that the treated group exhibited more pronounced signs of lesion resolution in the early period, but this pattern did not persist throughout the treatment. The results of the present study demonstrate that A. chica has cytotoxic and leishmanicidal potential but its healing effect must be better studied.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 12 17%
Student > Ph. D. Student 10 14%
Student > Master 9 13%
Student > Bachelor 9 13%
Researcher 6 8%
Other 9 13%
Unknown 17 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 15%
Pharmacology, Toxicology and Pharmaceutical Science 8 11%
Medicine and Dentistry 8 11%
Biochemistry, Genetics and Molecular Biology 7 10%
Chemistry 6 8%
Other 9 13%
Unknown 23 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2016.
All research outputs
#1,543,294
of 8,435,952 outputs
Outputs from BMC Complementary and Alternative Medicine
#424
of 2,129 outputs
Outputs of similar age
#68,220
of 320,941 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#18
of 116 outputs
Altmetric has tracked 8,435,952 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,129 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.