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Interleukin-18 modulation in autism spectrum disorders

Overview of attention for article published in Journal of Neuroinflammation, January 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#10 of 2,546)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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249 tweeters

Citations

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21 Dimensions

Readers on

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70 Mendeley
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Title
Interleukin-18 modulation in autism spectrum disorders
Published in
Journal of Neuroinflammation, January 2016
DOI 10.1186/s12974-015-0466-6
Pubmed ID
Authors

Rita Businaro, Mariangela Corsi, Gabriella Azzara, Tania Di Raimo, Giovanni Laviola, Emilia Romano, Lidia Ricci, Mauro Maccarrone, Eleonora Aronica, Andrea Fuso, Serafino Ricci

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disease which affects 1 in 88 children. Its etiology remains basically unknown, but it is apparent that neuroinflammation is involved in disease development. Great attention has been focused on pro-inflammatory cytokines, and several studies have reported their dysfunction unbalance in serum as well as in the brain. The present work aimed at evaluating putative dysregulation of interleukin-18 (IL-18), a pro-inflammatory cytokine of the IL-1 family in the sera of patients with ASD of different grades, compared to healthy controls, as well as in postmortem brain samples obtained from patients with tuberous sclerosis as well as acute inflammatory diseases. Moreover, quantitative analysis of IL-18 was performed in the sera and brain obtained from Reeler mice, an experimental model of autism. Serum IL-18 levels were measured by ELISA. IL-18 was localized by immunohistochemical analysis in brain sections obtained from tuberous sclerosis and encephalitis patients, as well as from gender- and age-matched controls, and in the brain sections of both Reeler and wild-type mice. IL-18 was also quantified by Western blots in homogenates of Reeler and wild-type mice brains. IL-18 binding protein (IL-18BP) was evaluated in Reeler and wild-type mice plasma as well as in their brains (sections and homogenates). IL-18 content decreased in the sera of patients with autism compared to healthy subjects and in Reeler sera compared to wild-type controls. IL-18 was detected within glial cells and neurons in the brain of subjects affected by tuberous sclerosis and encephalitis whereas in healthy subjects, only a weak IL-18 positivity was detected at the level of glial cells. Western blot identified higher amounts of IL-18 in Reeler brain homogenates compared to wild-type littermates. IL-18BP was expressed in higher amounts in Reeler brain compared to the brain of wild-type mice, whereas no significant difference was detected comparing IL-18BP plasma levels. IL-18 is dysregulated in ASD patients. Further studies seemed necessary to clarify the molecular details behind IL-18 increase in the brain and IL-18 decrease in the sera of patients. An increase in the size of the patient cohort seems necessary to ascertain whether decreased IL-18 content in the sera can become a predictive biomarker of ASD and whether its measure, in combination with other markers (e.g., increased levels of brain-derived neurotrophic factor (BDNF)), may be included in a diagnostic panel.

Twitter Demographics

The data shown below were collected from the profiles of 249 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Jordan 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 16%
Student > Master 11 16%
Student > Bachelor 11 16%
Student > Ph. D. Student 7 10%
Other 3 4%
Other 13 19%
Unknown 14 20%
Readers by discipline Count As %
Medicine and Dentistry 16 23%
Neuroscience 14 20%
Psychology 8 11%
Biochemistry, Genetics and Molecular Biology 4 6%
Agricultural and Biological Sciences 3 4%
Other 12 17%
Unknown 13 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 168. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2022.
All research outputs
#188,757
of 22,101,071 outputs
Outputs from Journal of Neuroinflammation
#10
of 2,546 outputs
Outputs of similar age
#3,740
of 406,806 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 190 outputs
Altmetric has tracked 22,101,071 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,546 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,806 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 190 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.