Title |
Impact of sub-inhibitory antibiotics on fibronectin-mediated host cell adhesion and invasion by Staphylococcus aureus
|
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Published in |
BMC Microbiology, December 2011
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DOI | 10.1186/1471-2180-11-263 |
Pubmed ID | |
Authors |
Jean Philippe Rasigade, Abdelmalek Moulay, Yannick Lhoste, Anne Tristan, Michele Bes, François Vandenesch, Jerome Etienne, Gerard Lina, Frederic Laurent, Oana Dumitrescu |
Abstract |
Staphylococcus aureus is a well-armed pathogen prevalent in severe infections such as endocarditis and osteomyelitis. Fibronectin-binding proteins A and B, encoded by fnbA/B, are major pathogenesis determinants in these infections through their involvement in S. aureus adhesion to and invasion of host cells. Sub-minimum inhibitory concentrations (sub-MICs) of antibiotics, frequently occurring in vivo because of impaired drug diffusion at the infection site, can alter S. aureus phenotype. We therefore investigated their impact on S. aureus fibronectin-mediated adhesiveness and invasiveness. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 19% |
Student > Ph. D. Student | 9 | 14% |
Researcher | 8 | 13% |
Student > Bachelor | 6 | 10% |
Professor > Associate Professor | 5 | 8% |
Other | 8 | 13% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 32% |
Immunology and Microbiology | 9 | 14% |
Medicine and Dentistry | 7 | 11% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 3 | 5% |
Unknown | 16 | 25% |