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Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

Overview of attention for article published in BMC Genomics, January 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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5 tweeters

Citations

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30 Dimensions

Readers on

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31 Mendeley
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Title
Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome
Published in
BMC Genomics, January 2016
DOI 10.1186/s12864-015-2354-y
Pubmed ID
Authors

Baoshan Xu, Madelaine Gogol, Karin Gaudenz, Jennifer L. Gerton

Abstract

Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 signaling was depressed and overall translation was reduced in RBS cells and zebrafish models for RBS. Treatment of RBS cells and zebrafish RBS models with L-leucine partially rescued mTOR function and protein synthesis, correlating with increased cell division and improved development. In this study, we use RBS cells to model mTORC1 repression and analyze transcription and translation with ribosome profiling to determine gene-level effects of L-leucine. L-leucine treatment partially rescued translational efficiency of ribosomal subunits, translation initiation factors, snoRNA production, and mitochondrial function in RBS cells, consistent with these processes being mTORC1 controlled. In contrast, other genes are differentially expressed independent of L-leucine treatment, including imprinted genes such as H19 and GTL2, miRNAs regulated by GTL2, HOX genes, and genes in nucleolar associated domains. Our study distinguishes between gene expression changes in RBS cells that are TOR dependent and those that are independent. Some of the TOR independent gene expression changes likely reflect the architectural role of cohesin in chromatin looping and gene expression. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS cells and supports that normal gene expression and translation requires ESCO2 function.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 26%
Student > Master 8 26%
Researcher 5 16%
Professor > Associate Professor 3 10%
Other 2 6%
Other 4 13%
Unknown 1 3%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 48%
Agricultural and Biological Sciences 8 26%
Medicine and Dentistry 4 13%
Computer Science 1 3%
Chemistry 1 3%
Other 1 3%
Unknown 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#2,231,222
of 8,603,451 outputs
Outputs from BMC Genomics
#1,872
of 6,018 outputs
Outputs of similar age
#95,293
of 323,074 outputs
Outputs of similar age from BMC Genomics
#101
of 322 outputs
Altmetric has tracked 8,603,451 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 6,018 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 322 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.