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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery
|
|---|---|
| Published in |
Critical Care, January 2016
|
| DOI | 10.1186/s13054-015-1172-6 |
| Pubmed ID | |
| Authors |
Giangiuseppe Cappabianca, Giovanni Mariscalco, Fausto Biancari, Daniele Maselli, Francesca Papesso, Marzia Cottini, Sandro Crosta, Simona Banescu, Aamer B. Ahmed, Cesare Beghi |
| Abstract |
Bleeding after cardiac surgery requiring surgical reexploration and blood component transfusion is associated with increased morbidity and mortality. Although prothrombin complex concentrate (PCC) has been used satisfactorily in bleeding disorders, studies on its efficacy and safety after cardiopulmonary bypass are limited. Between January 2005 and December 2013, 3454 consecutive cardiac surgery patients were included in an observational study aimed at investigating the efficacy and safety of PCC as first-line coagulopathy treatment as a replacement for fresh frozen plasma (FFP). Starting in January 2012, PCC was introduced as solely first-line treatment for bleeding following cardiac surgery. After one-to-one propensity score-matched analysis, 225 pairs of patients receiving PCC (median dose 1500 IU) and FFP (median dose 2 U) were included. The use of PCC was associated with significantly decreased 24-h post-operative blood loss (836 ± 1226 vs. 935 ± 583 ml, p < 0.0001). Propensity score-adjusted multivariate analysis showed that PCC was associated with significantly lower risk of red blood cell (RBC) transfusions (odds ratio [OR] 0.50; 95 % confidence interval [CI] 0.31-0.80), decreased amount of RBC units (β unstandardised coefficient -1.42, 95 % CI -2.06 to -0.77) and decreased risk of transfusion of more than 2 RBC units (OR 0.53, 95 % CI 0.38-0.73). Patients receiving PCC had an increased risk of post-operative acute kidney injury (AKI) (OR 1.44, 95 % CI 1.02-2.05) and renal replacement therapy (OR 3.35, 95 % CI 1.13-9.90). Hospital mortality was unaffected by PCC (OR 1.51, 95 % CI 0.84-2.72). In the cardiac surgery setting, the use of PCC compared with FFP was associated with decreased post-operative blood loss and RBC transfusion requirements. However, PCC administration may be associated with a higher risk of post-operative AKI. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 6% |
| Costa Rica | 2 | 6% |
| United Kingdom | 2 | 6% |
| United States | 2 | 6% |
| India | 1 | 3% |
| Ecuador | 1 | 3% |
| Malaysia | 1 | 3% |
| Australia | 1 | 3% |
| Denmark | 1 | 3% |
| Other | 6 | 17% |
| Unknown | 17 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 53% |
| Practitioners (doctors, other healthcare professionals) | 12 | 33% |
| Scientists | 3 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 95 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 20 | 21% |
| Researcher | 12 | 13% |
| Professor | 8 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Other | 24 | 25% |
| Unknown | 19 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 60% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Arts and Humanities | 2 | 2% |
| Unspecified | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 22 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2016.
All research outputs
#1,711,294
of 25,374,917 outputs
Outputs from Critical Care
#1,506
of 6,554 outputs
Outputs of similar age
#28,868
of 400,126 outputs
Outputs of similar age from Critical Care
#114
of 495 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 495 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.