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Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation

Overview of attention for article published in Journal of Neuroinflammation, January 2016
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Title
Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation
Published in
Journal of Neuroinflammation, January 2016
DOI 10.1186/s12974-015-0469-3
Pubmed ID
Authors

Kelsey M. Greathouse, Steven P. Palladino, Chaoling Dong, Eric S. Helton, Eroboghene E. Ubogu

Abstract

Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge, advancements in molecular biology and progress in developing specific drugs for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, there are currently no specific therapies that modulate pathogenic peripheral nerve inflammation. Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 15%
Student > Master 6 13%
Student > Bachelor 6 13%
Researcher 5 10%
Student > Doctoral Student 4 8%
Other 11 23%
Unknown 9 19%
Readers by discipline Count As %
Medicine and Dentistry 8 17%
Neuroscience 8 17%
Agricultural and Biological Sciences 6 13%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Other 9 19%
Unknown 9 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#15,685,238
of 23,308,124 outputs
Outputs from Journal of Neuroinflammation
#1,787
of 2,691 outputs
Outputs of similar age
#233,418
of 396,144 outputs
Outputs of similar age from Journal of Neuroinflammation
#52
of 83 outputs
Altmetric has tracked 23,308,124 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,691 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,144 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.