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Roles of cofactors and chromatin accessibility in Hox protein target specificity

Overview of attention for article published in Epigenetics & Chromatin, January 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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Title
Roles of cofactors and chromatin accessibility in Hox protein target specificity
Published in
Epigenetics & Chromatin, January 2016
DOI 10.1186/s13072-015-0049-x
Pubmed ID
Authors

Ching Yew Beh, Sherif El-Sharnouby, Aikaterini Chatzipli, Steven Russell, Siew Woh Choo, Robert White

Abstract

The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood. This is well illustrated by the Hox family of transcription factors as their limited in vitro DNA-binding specificity contrasts with their clear in vivo functional specificity. We generated genome-wide binding profiles for three Hox proteins, Ubx, Abd-A and Abd-B, following transient expression in Drosophila Kc167 cells, revealing clear target specificity and a striking influence of chromatin accessibility. In the absence of the TALE class homeodomain cofactors Exd and Hth, Ubx and Abd-A bind at a very similar set of target sites in accessible chromatin, whereas Abd-B binds at an additional specific set of targets. Provision of Hox cofactors Exd and Hth considerably modifies the Ubx genome-wide binding profile enabling Ubx to bind at an additional novel set of targets. Both the Abd-B specific targets and the cofactor-dependent Ubx targets are in chromatin that is relatively DNase1 inaccessible prior to the expression of Hox proteins/Hox cofactors. Our experiments demonstrate a strong role for chromatin accessibility in Hox protein binding and suggest that Hox protein competition with nucleosomes has a major role in Hox protein target specificity in vivo.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Turkey 1 2%
Brazil 1 2%
Unknown 43 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 30%
Student > Bachelor 8 17%
Researcher 7 15%
Student > Master 5 11%
Student > Doctoral Student 3 7%
Other 2 4%
Unknown 7 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 46%
Biochemistry, Genetics and Molecular Biology 12 26%
Medicine and Dentistry 2 4%
Computer Science 2 4%
Business, Management and Accounting 1 2%
Other 2 4%
Unknown 6 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2016.
All research outputs
#3,239,457
of 23,577,654 outputs
Outputs from Epigenetics & Chromatin
#112
of 574 outputs
Outputs of similar age
#57,324
of 397,096 outputs
Outputs of similar age from Epigenetics & Chromatin
#3
of 17 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 574 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,096 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.