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Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures

Overview of attention for article published in BMC Genomics, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
1 news outlet
twitter
10 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
19 Mendeley
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Title
Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures
Published in
BMC Genomics, January 2016
DOI 10.1186/s12864-015-1920-7
Pubmed ID
Authors

Ndongo Dia, Laurence Lavie, Ngor Faye, Guy Méténier, Edouard Yeramian, Christophe Duroure, Bhen S. Toguebaye, Roger Frutos, Mbayame N. Niang, Christian P. Vivarès, Choukri Ben Mamoun, Emmanuel Cornillot

Abstract

The microsporidian Encephalitozoon cuniculi is an obligate intracellular eukaryotic pathogen with a small nuclear genome (2.9 Mbp) consisting of 11 chromosomes. Although each chromosome end is known to contain a single rDNA unit, the incomplete assembly of subtelomeric regions following sequencing of the genome identified only 3 of the 22 expected rDNA units. While chromosome end assembly remains a difficult process in most eukaryotic genomes, it is of significant importance for pathogens because these regions encode factors important for virulence and host evasion. Here we report the first complete assembly of E. cuniculi chromosome ends, and describe a novel mosaic structure of segmental duplications (EXT repeats) in these regions. EXT repeats range in size between 3.5 and 23.8 kbp and contain four multigene families encoding membrane associated proteins. Twenty-one recombination sites were identified in the sub-terminal region of E. cuniculi chromosomes. Our analysis suggests that these sites contribute to the diversity of chromosome ends organization through Double Strand Break repair mechanisms. The region containing EXT repeats at chromosome extremities can be differentiated based on gene composition, GC content, recombination sites density and chromosome landscape. Together this study provides the complete structure of the chromosome ends of E. cuniculi GB-M1, and identifies important factors, which could play a major role in parasite diversity and host-parasite interactions. Comparison with other eukaryotic genomes suggests that terminal regions could be distinguished precisely based on gene content, genetic instability and base composition biais. The diversity of processes assciated with chromosome extremities and their biological consequences, as they are presented in the present study, emphasize the fact that great effort will be necessary in the future to characterize more carefully these regions during whole genome sequencing efforts.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 5%
United States 1 5%
Canada 1 5%
Unknown 16 84%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Researcher 4 21%
Student > Ph. D. Student 3 16%
Professor 2 11%
Professor > Associate Professor 2 11%
Other 3 16%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 42%
Biochemistry, Genetics and Molecular Biology 5 26%
Medicine and Dentistry 2 11%
Immunology and Microbiology 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Other 0 0%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2019.
All research outputs
#1,737,482
of 21,619,833 outputs
Outputs from BMC Genomics
#471
of 10,371 outputs
Outputs of similar age
#36,158
of 404,731 outputs
Outputs of similar age from BMC Genomics
#49
of 1,163 outputs
Altmetric has tracked 21,619,833 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,371 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1,163 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.