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Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

Overview of attention for article published in BMC Molecular and Cell Biology, January 2016
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Title
Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells
Published in
BMC Molecular and Cell Biology, January 2016
DOI 10.1186/s12860-015-0078-0
Pubmed ID
Authors

Katarzyna Plak, Henderikus Pots, Peter J. M. Van Haastert, Arjan Kortholt

Abstract

The small G-protein Rap1 is an important regulator of cellular adhesion in Dictyostelium, however so far the downstream signalling pathways for cell adhesion are not completely characterized. In mammalian cells talin is crucial for adhesion and Rap1 was shown to be a key regulator of talin signalling. In a proteomic screen we identified TalinB as a potential Rap1 effector in Dictyostelium. In subsequent pull-down experiments we demonstrate that the Ras association (RA) domain of TalinB interacts specifically with active Rap1. Studies with a mutated RA domain revealed that the RA domain is essential for TalinB-Rap1 interaction, and that this interaction contributes to cell-substrate adhesion during single-celled growth and is crucial for cell-cell adhesion during multicellular development. Dictyostelium Rap1 directly binds to TalinB via the conserved RA domain. This interaction is critical for adhesion, which becomes essential for high adhesive force demanding processes, like morphogenesis during multicellular development of Dictyostelium. In mammalian cells the established Rap1-talin interaction is indirect and acts through the scaffold protein - RIAM. Interestingly, direct binding of mouse Rap1 to the RA domain of Talin1 has recently been demonstrated.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 24%
Student > Master 7 18%
Researcher 7 18%
Student > Bachelor 5 13%
Professor > Associate Professor 3 8%
Other 5 13%
Unknown 2 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 42%
Agricultural and Biological Sciences 14 37%
Medicine and Dentistry 3 8%
Immunology and Microbiology 1 3%
Engineering 1 3%
Other 0 0%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#896
of 1,233 outputs
Outputs of similar age
#278,579
of 400,078 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#10
of 19 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,078 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.