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Targeting the indoleamine 2,3-dioxygenase pathway in cancer

Overview of attention for article published in Journal for Immunotherapy of Cancer, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
twitter
28 tweeters
patent
4 patents
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
267 Dimensions

Readers on

mendeley
299 Mendeley
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Title
Targeting the indoleamine 2,3-dioxygenase pathway in cancer
Published in
Journal for Immunotherapy of Cancer, December 2015
DOI 10.1186/s40425-015-0094-9
Pubmed ID
Authors

Yong Wha Moon, Joud Hajjar, Patrick Hwu, Aung Naing

Abstract

Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 299 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 <1%
Italy 1 <1%
France 1 <1%
Unknown 295 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 17%
Researcher 48 16%
Student > Master 37 12%
Student > Bachelor 34 11%
Other 22 7%
Other 56 19%
Unknown 52 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 57 19%
Medicine and Dentistry 55 18%
Agricultural and Biological Sciences 36 12%
Immunology and Microbiology 33 11%
Pharmacology, Toxicology and Pharmaceutical Science 19 6%
Other 39 13%
Unknown 60 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2022.
All research outputs
#1,151,297
of 24,119,703 outputs
Outputs from Journal for Immunotherapy of Cancer
#273
of 3,204 outputs
Outputs of similar age
#20,327
of 398,577 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#1
of 75 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,204 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,577 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.