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Targeting the indoleamine 2,3-dioxygenase pathway in cancer

Overview of attention for article published in Journal for Immunotherapy of Cancer, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
1 news outlet
twitter
36 tweeters
patent
4 patents
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
238 Dimensions

Readers on

mendeley
280 Mendeley
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Title
Targeting the indoleamine 2,3-dioxygenase pathway in cancer
Published in
Journal for Immunotherapy of Cancer, December 2015
DOI 10.1186/s40425-015-0094-9
Pubmed ID
Authors

Yong Wha Moon, Joud Hajjar, Patrick Hwu, Aung Naing

Abstract

Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.

Twitter Demographics

The data shown below were collected from the profiles of 36 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 <1%
Italy 1 <1%
France 1 <1%
Unknown 276 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 17%
Researcher 47 17%
Student > Master 36 13%
Student > Bachelor 32 11%
Other 22 8%
Other 51 18%
Unknown 44 16%
Readers by discipline Count As %
Medicine and Dentistry 55 20%
Biochemistry, Genetics and Molecular Biology 53 19%
Agricultural and Biological Sciences 36 13%
Immunology and Microbiology 32 11%
Pharmacology, Toxicology and Pharmaceutical Science 18 6%
Other 33 12%
Unknown 53 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2022.
All research outputs
#875,966
of 21,949,878 outputs
Outputs from Journal for Immunotherapy of Cancer
#191
of 2,707 outputs
Outputs of similar age
#18,540
of 406,448 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#2
of 109 outputs
Altmetric has tracked 21,949,878 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,707 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,448 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.