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Roles of low-density lipoprotein receptor-related protein 1 in tumors

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, January 2016
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Title
Roles of low-density lipoprotein receptor-related protein 1 in tumors
Published in
Ai zheng Aizheng Chinese journal of cancer, January 2016
DOI 10.1186/s40880-015-0064-0
Pubmed ID
Authors

Peipei Xing, Zhichao Liao, Zhiwu Ren, Jun Zhao, Fengju Song, Guowen Wang, Kexin Chen, Jilong Yang

Abstract

Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such as hepatocytes, fibroblasts, neurons, astrocytes, macrophages, smooth muscle cells, and malignant cells. Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in many processes that drive tumorigenesis and tumor progression. For example, LRP1 not only promotes tumor cell migration and invasion by regulating matrix metalloproteinase (MMP)-2 and MMP-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor, the serine/threonine protein kinase signaling pathway, and the expression of Caspase-3. LRP1-mediated phosphorylation of the extracellular signal-regulated kinase pathway and c-jun N-terminal kinase are also involved in tumor cell proliferation and invasion. In addition, LRP1 has been shown to be down-regulated by microRNA-205 and methylation of LRP1 CpG islands. Furthermore, a novel fusion gene, LRP1-SNRNP25, promotes osteosarcoma cell invasion and migration. Only by understanding the mechanisms of these effects can we develop novel diagnostic and therapeutic strategies for cancers mediated by LRP1.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 20%
Researcher 9 15%
Student > Master 6 10%
Student > Bachelor 5 8%
Student > Doctoral Student 3 5%
Other 6 10%
Unknown 20 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 18%
Agricultural and Biological Sciences 10 16%
Immunology and Microbiology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Medicine and Dentistry 2 3%
Other 10 16%
Unknown 20 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#20,300,248
of 22,837,982 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#211
of 264 outputs
Outputs of similar age
#330,512
of 393,663 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#11
of 12 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 264 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,663 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.