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Roles of low‐density lipoprotein receptor‐related protein 1 in tumors

Overview of attention for article published in Cancer Communications, January 2016
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Title
Roles of low‐density lipoprotein receptor‐related protein 1 in tumors
Published in
Cancer Communications, January 2016
DOI 10.1186/s40880-015-0064-0
Pubmed ID
Authors

Peipei Xing, Zhichao Liao, Zhiwu Ren, Jun Zhao, Fengju Song, Guowen Wang, Kexin Chen, Jilong Yang

Abstract

Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such as hepatocytes, fibroblasts, neurons, astrocytes, macrophages, smooth muscle cells, and malignant cells. Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in many processes that drive tumorigenesis and tumor progression. For example, LRP1 not only promotes tumor cell migration and invasion by regulating matrix metalloproteinase (MMP)-2 and MMP-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor, the serine/threonine protein kinase signaling pathway, and the expression of Caspase-3. LRP1-mediated phosphorylation of the extracellular signal-regulated kinase pathway and c-jun N-terminal kinase are also involved in tumor cell proliferation and invasion. In addition, LRP1 has been shown to be down-regulated by microRNA-205 and methylation of LRP1 CpG islands. Furthermore, a novel fusion gene, LRP1-SNRNP25, promotes osteosarcoma cell invasion and migration. Only by understanding the mechanisms of these effects can we develop novel diagnostic and therapeutic strategies for cancers mediated by LRP1.

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The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 21%
Researcher 8 11%
Student > Master 7 9%
Student > Bachelor 5 7%
Student > Doctoral Student 4 5%
Other 9 12%
Unknown 26 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 17%
Agricultural and Biological Sciences 10 13%
Medicine and Dentistry 5 7%
Immunology and Microbiology 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 13 17%
Unknown 26 35%