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The non-structural protein μNS of piscine orthoreovirus (PRV) forms viral factory-like structures

Overview of attention for article published in Veterinary Research, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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2 tweeters
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1 patent
wikipedia
1 Wikipedia page

Citations

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19 Dimensions

Readers on

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28 Mendeley
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Title
The non-structural protein μNS of piscine orthoreovirus (PRV) forms viral factory-like structures
Published in
Veterinary Research, January 2016
DOI 10.1186/s13567-015-0302-0
Pubmed ID
Authors

Hanne Merethe Haatveit, Ingvild B. Nyman, Turhan Markussen, Øystein Wessel, Maria Krudtaa Dahle, Espen Rimstad

Abstract

Piscine orthoreovirus (PRV) is associated with heart- and skeletal muscle inflammation in farmed Atlantic salmon. The virus is ubiquitous and found in both farmed and wild salmonid fish. It belongs to the family Reoviridae, closely related to the genus Orthoreovirus. The PRV genome comprises ten double-stranded RNA segments encoding at least eight structural and two non-structural proteins. Erythrocytes are the major target cells for PRV. Infected erythrocytes contain globular inclusions resembling viral factories; the putative site of viral replication. For the mammalian reovirus (MRV), the non-structural protein μNS is the primary organizer in factory formation. The analogous PRV protein was the focus of the present study. The subcellular location of PRV μNS and its co-localization with the PRV σNS, µ2 and λ1 proteins was investigated. We demonstrated that PRV μNS forms dense globular cytoplasmic inclusions in transfected fish cells, resembling the viral factories of MRV. In co-transfection experiments with μNS, the σNS, μ2 and λ1 proteins were recruited to the globular structures. The ability of μNS to recruit other PRV proteins into globular inclusions indicates that it is the main viral protein involved in viral factory formation and pivotal in early steps of viral assembly.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Master 4 14%
Student > Bachelor 4 14%
Other 2 7%
Student > Ph. D. Student 2 7%
Other 6 21%
Unknown 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 36%
Veterinary Science and Veterinary Medicine 5 18%
Immunology and Microbiology 4 14%
Biochemistry, Genetics and Molecular Biology 2 7%
Computer Science 1 4%
Other 1 4%
Unknown 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2021.
All research outputs
#3,674,232
of 20,756,397 outputs
Outputs from Veterinary Research
#151
of 1,117 outputs
Outputs of similar age
#73,109
of 398,940 outputs
Outputs of similar age from Veterinary Research
#14
of 110 outputs
Altmetric has tracked 20,756,397 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,117 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,940 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.