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Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo

Overview of attention for article published in Malaria Journal, January 2016
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Title
Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo
Published in
Malaria Journal, January 2016
DOI 10.1186/s12936-015-1072-x
Pubmed ID
Authors

Henry M. T. Ntuku, Gianfrancesco Ferrari, Christian Burri, Antoinette K. Tshefu, Didier M. Kalemwa, Christian Lengeler

Abstract

The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country is now planning to deploy nationwide injectable artesunate as the preferred treatment for the management of severe malaria. To support this process, the feasibility and acceptability of the use of injectable artesunate in the context of the DRC was assessed, from the perspective of both health care providers and patients/caretakers. Questionnaires and observations were used to collect information from health care providers and patients/caretakers in eight health facilities in the Province of Kinshasa and in the Province of Bas-Congo. A total of 31 health care providers and 134 patients/care takers were interviewed. Seventy five percent (75 %) of health care providers found it less difficult to prepare injectable artesunate compared to quinine. None of them encountered problems during preparation and administration of injectable artesunate. The large majority of care providers (93 %) and patients/caretakers (93 %) answered that injectable artesunate took less time than quinine to cure the symptoms of the patients. 26 (84 %) health care providers reported that the personnel workload had diminished with the use of injectable artesunate. 7 (22.6 %) health workers reported adverse drug reactions, of which a decrease in the haemoglobin rate was the most common (71.4 %). All care providers and the vast majority of patients/caretakers (96 %, N = 128) were either satisfied or very satisfied with injectable artesunate. These findings show that the use of injectable artesunate for the treatment of severe malaria is feasible and acceptable in the context of DRC, with appropriate training of care providers. Both care providers and patients/caretakers perceived injectable artesunate to be effective and safe, thus promoting acceptability.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 22%
Student > Bachelor 10 16%
Other 7 11%
Student > Doctoral Student 5 8%
Researcher 5 8%
Other 15 24%
Unknown 7 11%
Readers by discipline Count As %
Medicine and Dentistry 27 43%
Pharmacology, Toxicology and Pharmaceutical Science 10 16%
Biochemistry, Genetics and Molecular Biology 3 5%
Social Sciences 3 5%
Nursing and Health Professions 3 5%
Other 9 14%
Unknown 8 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2016.
All research outputs
#17,780,575
of 22,837,982 outputs
Outputs from Malaria Journal
#4,860
of 5,572 outputs
Outputs of similar age
#267,635
of 393,791 outputs
Outputs of similar age from Malaria Journal
#130
of 168 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,572 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,791 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 168 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.