@AlectorTx have partnered with @GSK to test an antibody to a protein called sortilin (SORT1) with a goal of ⬆️ levels of a protein called progranulin (GRN), that may have value in slowing ALS disease course. https://t.co/ZRkPumHUDK https://t.co/fBYtFOFXhk
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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice. https://t.co/vYA7WTsBe8
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RT @CBD_VIB: @MolNeuro @KU_Leuven @DeStrooperLab The second paper reveals the neuroprotective effects of progranulin against TDP-43 accumul…
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@MolNeuro @KU_Leuven @DeStrooperLab The second paper reveals the neuroprotective effects of progranulin against TDP-43 accumulation and neurodegeneration in mice, suggesting that progranulin treatment may benefit not only patients with certain forms of FTD