Title |
Sub-cellular internalization and organ specific oral delivery of PABA nanoparticles by side chain variation
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Published in |
Journal of Nanobiotechnology, March 2011
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DOI | 10.1186/1477-3155-9-10 |
Pubmed ID | |
Authors |
Jhillu S Yadav, Pragna P Das, T Lakshminarayan Reddy, Indira Bag, Priyadarshini M Lavanya, Bulusu Jagannadh, Debendra K Mohapatra, Manika Pal Bhadra, Utpal Bhadra |
Abstract |
Organic nanomaterials having specific biological properties play important roles in in vivo delivery and clearance from the live cells. To develop orally deliverable nanomaterials for different biological applications, we have synthesized several fluorescently labelled, self-assembled PABA nanoparticles using possible acid side chain combinations and tested against insect and human cell lines and in vivo animal model. Flurophores attached to nanostructures help in rapid in vivo screening and tracking through complex tissues. The sub-cellular internalization mechanism of the conjugates was determined. A set of physio-chemical parameters of engineered nanoskeletons were also defined that is critical for preferred uptake in multiple organs of live Drosophila. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 38% |
Student > Postgraduate | 2 | 15% |
Researcher | 2 | 15% |
Professor | 1 | 8% |
Student > Master | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 31% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Computer Science | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |