↓ Skip to main content

Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Overview of attention for article published in Journal of the International Society of Sports Nutrition, April 2022
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#46 of 940)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
39 news outlets
twitter
14 X users
facebook
5 Facebook pages
wikipedia
6 Wikipedia pages
reddit
1 Redditor
video
2 YouTube creators

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
167 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use
Published in
Journal of the International Society of Sports Nutrition, April 2022
DOI 10.1186/s12970-016-0113-3
Pubmed ID
Authors

Lem Taylor, Petey Mumford, Mike Roberts, Sara Hayward, Jacy Mullins, Stacie Urbina, Colin Wilborn

Abstract

Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, and motivation to exercise. The purpose of this study was to examine the safety and non-habituating effects of TeaCrine®, a nature-identical, chemically equivalent bioactive version of theacrine. Sixty healthy men (mean ± SD age, height, weight: 22.9 ± 4.7 years, 183.5 ± 9.2 cm, 86.5 ± 13.7 kg) and women (22.3 ± 4.5 years, 165.2 ± 12.3 cm, 69.0 ± 17.4 kg) were placed into one of three groups: placebo (PLA, n = 20), 200 mg TeaCrine® (LD, n = 19) or 300 mg Teacrine® (HD, n = 21) and ingested their respective supplement once daily for 8 weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potential tachyphylactic responses and habituation effects. Data were analyzed via two-way (group × time) ANOVAs and statistical significance was accepted at p < 0.05. All values for clinical safety markers fell within normal limits and no group × time interactions were noted. No evidence of habituation was noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable in all groups across the 8-week study protocol. These findings support the clinical safety and non-habituating neuro-energetic effects of TeaCrine® supplementation over 8 weeks of daily use (up to 300 mg/day). Moreover, there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Brazil 1 <1%
Unknown 165 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 34 20%
Student > Master 20 12%
Researcher 17 10%
Other 10 6%
Student > Postgraduate 7 4%
Other 24 14%
Unknown 55 33%
Readers by discipline Count As %
Nursing and Health Professions 25 15%
Medicine and Dentistry 25 15%
Sports and Recreations 24 14%
Biochemistry, Genetics and Molecular Biology 9 5%
Agricultural and Biological Sciences 8 5%
Other 14 8%
Unknown 62 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 307. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2023.
All research outputs
#109,967
of 25,134,448 outputs
Outputs from Journal of the International Society of Sports Nutrition
#46
of 940 outputs
Outputs of similar age
#3,518
of 436,822 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#45
of 850 outputs
Altmetric has tracked 25,134,448 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 940 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 63.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 436,822 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 850 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.