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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use
|
|---|---|
| Published in |
Journal of the International Society of Sports Nutrition, April 2022
|
| DOI | 10.1186/s12970-016-0113-3 |
| Pubmed ID | |
| Authors |
Lem Taylor, Petey Mumford, Mike Roberts, Sara Hayward, Jacy Mullins, Stacie Urbina, Colin Wilborn |
| Abstract |
Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, and motivation to exercise. The purpose of this study was to examine the safety and non-habituating effects of TeaCrine®, a nature-identical, chemically equivalent bioactive version of theacrine. Sixty healthy men (mean ± SD age, height, weight: 22.9 ± 4.7 years, 183.5 ± 9.2 cm, 86.5 ± 13.7 kg) and women (22.3 ± 4.5 years, 165.2 ± 12.3 cm, 69.0 ± 17.4 kg) were placed into one of three groups: placebo (PLA, n = 20), 200 mg TeaCrine® (LD, n = 19) or 300 mg Teacrine® (HD, n = 21) and ingested their respective supplement once daily for 8 weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potential tachyphylactic responses and habituation effects. Data were analyzed via two-way (group × time) ANOVAs and statistical significance was accepted at p < 0.05. All values for clinical safety markers fell within normal limits and no group × time interactions were noted. No evidence of habituation was noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable in all groups across the 8-week study protocol. These findings support the clinical safety and non-habituating neuro-energetic effects of TeaCrine® supplementation over 8 weeks of daily use (up to 300 mg/day). Moreover, there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| Spain | 2 | 14% |
| Unknown | 8 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 57% |
| Practitioners (doctors, other healthcare professionals) | 4 | 29% |
| Scientists | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 167 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 33 | 20% |
| Student > Master | 21 | 12% |
| Researcher | 16 | 9% |
| Other | 10 | 6% |
| Professor | 7 | 4% |
| Other | 31 | 18% |
| Unknown | 51 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 26 | 15% |
| Sports and Recreations | 25 | 15% |
| Medicine and Dentistry | 24 | 14% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Agricultural and Biological Sciences | 8 | 5% |
| Other | 19 | 11% |
| Unknown | 59 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 307. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2023.
All research outputs
#107,472
of 24,753,534 outputs
Outputs from Journal of the International Society of Sports Nutrition
#45
of 929 outputs
Outputs of similar age
#3,468
of 435,278 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#44
of 850 outputs
Altmetric has tracked 24,753,534 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 929 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 63.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 435,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 850 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.