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Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Overview of attention for article published in Journal of the International Society of Sports Nutrition, April 2022
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#37 of 887)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
39 news outlets
twitter
13 tweeters
facebook
5 Facebook pages
wikipedia
5 Wikipedia pages
reddit
1 Redditor
video
2 video uploaders

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
149 Mendeley
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Title
Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use
Published in
Journal of the International Society of Sports Nutrition, April 2022
DOI 10.1186/s12970-016-0113-3
Pubmed ID
Authors

Lem Taylor, Petey Mumford, Mike Roberts, Sara Hayward, Jacy Mullins, Stacie Urbina, Colin Wilborn

Abstract

Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, and motivation to exercise. The purpose of this study was to examine the safety and non-habituating effects of TeaCrine®, a nature-identical, chemically equivalent bioactive version of theacrine. Sixty healthy men (mean ± SD age, height, weight: 22.9 ± 4.7 years, 183.5 ± 9.2 cm, 86.5 ± 13.7 kg) and women (22.3 ± 4.5 years, 165.2 ± 12.3 cm, 69.0 ± 17.4 kg) were placed into one of three groups: placebo (PLA, n = 20), 200 mg TeaCrine® (LD, n = 19) or 300 mg Teacrine® (HD, n = 21) and ingested their respective supplement once daily for 8 weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potential tachyphylactic responses and habituation effects. Data were analyzed via two-way (group × time) ANOVAs and statistical significance was accepted at p < 0.05. All values for clinical safety markers fell within normal limits and no group × time interactions were noted. No evidence of habituation was noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable in all groups across the 8-week study protocol. These findings support the clinical safety and non-habituating neuro-energetic effects of TeaCrine® supplementation over 8 weeks of daily use (up to 300 mg/day). Moreover, there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Brazil 1 <1%
Unknown 147 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 31 21%
Student > Master 20 13%
Researcher 13 9%
Other 9 6%
Student > Ph. D. Student 8 5%
Other 29 19%
Unknown 39 26%
Readers by discipline Count As %
Sports and Recreations 25 17%
Nursing and Health Professions 24 16%
Medicine and Dentistry 20 13%
Agricultural and Biological Sciences 8 5%
Biochemistry, Genetics and Molecular Biology 6 4%
Other 20 13%
Unknown 46 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 306. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#94,108
of 23,035,022 outputs
Outputs from Journal of the International Society of Sports Nutrition
#37
of 887 outputs
Outputs of similar age
#3,188
of 440,393 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#36
of 851 outputs
Altmetric has tracked 23,035,022 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 887 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 58.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 851 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.