Title |
Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture
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Published in |
Molecular Pain, January 2011
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DOI | 10.1186/1744-8069-7-98 |
Pubmed ID | |
Authors |
Tang-feng Su, Ling-hong Zhang, Miao Peng, Cai-hua Wu, Wen Pan, Bo Tian, Jing Shi, Hui-lin Pan, Man Li |
Abstract |
Electroacupuncture (EA) can produce analgesia by increasing the β-endorphin level and activation of peripheral μ-opioid receptors in inflamed tissues. Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are also involved in the antinociceptive effect of EA on inflammatory pain. However, little is known about how peripheral CB2Rs interact with the endogenous opioid system at the inflammatory site and how this interaction contributes to the antinociceptive effect of EA on inflammatory pain. In this study, we determined the role of peripheral CB2Rs in the effects of EA on the expression of β-endorphin in inflamed skin tissues and inflammatory pain. |
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