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HDACi and Nrf2: not from alpha to omega but from acetylation to OA

Overview of attention for article published in Arthritis Research & Therapy, December 2015
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1 tweeter

Citations

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Title
HDACi and Nrf2: not from alpha to omega but from acetylation to OA
Published in
Arthritis Research & Therapy, December 2015
DOI 10.1186/s13075-015-0885-x
Pubmed ID
Authors

Holger Jahr

Abstract

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is probably the most important ubiquitously expressed little protein that you have never heard of. Discovered more than 20 years ago, it is now known as a master regulator of redox homeostasis, controlling a plethora of cytoprotective phase II anti-oxidant enzymes. Regulation of gene expression by histone acetyltransferases and histone deacetylases drives the etiology of many age-related human diseases, including osteoarthritis. In Arthritis Research & Therapy, Cai et al. explore systemic histone deacetylase inhibition as a strategy to prevent osteoarthritis and identify a role for Nrf2 in preventing cartilage degeneration.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 18%
Student > Doctoral Student 2 18%
Student > Bachelor 1 9%
Student > Master 1 9%
Unknown 5 45%
Readers by discipline Count As %
Environmental Science 1 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Nursing and Health Professions 1 9%
Agricultural and Biological Sciences 1 9%
Other 2 18%
Unknown 4 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2016.
All research outputs
#9,295,224
of 11,622,318 outputs
Outputs from Arthritis Research & Therapy
#1,512
of 1,602 outputs
Outputs of similar age
#228,645
of 331,972 outputs
Outputs of similar age from Arthritis Research & Therapy
#97
of 109 outputs
Altmetric has tracked 11,622,318 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,602 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,972 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.