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First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells

Overview of attention for article published in Head & Face Medicine, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 302)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
4 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
182 Mendeley
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Title
First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells
Published in
Head & Face Medicine, January 2016
DOI 10.1186/s13005-016-0101-5
Pubmed ID
Authors

Wataru Katagiri, Masashi Osugi, Takamasa Kawai, Hideharu Hibi

Abstract

Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement. The protocol of this clinical study was approved by the ethics committee of Nagoya University Hospital. MSC-CM was prepared from conditioned medium from commercially available human bone marrow-derived MSCs. Patients were treated with beta-tricalcuim phosphate (β-TCP) or an atelocollagen sponge soaked with MSC-CM. Clinical and radiographic assessments were performed during the follow-up period. Histological assessments were also performed in some cases. Clinical and histological data from patients who underwent the SFE procedure without MSC-CM were also used retrospectively as reference controls. MSC-CM contained several cytokines such as insulin-like growth factor-1, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor in relatively low amounts. No systemic or local complications were reported throughout the study. Radiographic evaluation revealed early bone formation in all cases. Histological evaluation also supported the radiographic findings. Furthermore, infiltration of inflammatory cells was scarce throughout the specimens. MSC-CM was used safely and with less inflammatory signs and appears to have great osteogenic potential for regenerative medicine of bone. This is the first in-human clinical study of alveolar bone regeneration using MSC-CM.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 179 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 30 16%
Student > Ph. D. Student 22 12%
Student > Bachelor 20 11%
Student > Postgraduate 15 8%
Other 15 8%
Other 49 27%
Unknown 31 17%
Readers by discipline Count As %
Medicine and Dentistry 83 46%
Biochemistry, Genetics and Molecular Biology 15 8%
Agricultural and Biological Sciences 12 7%
Materials Science 7 4%
Engineering 7 4%
Other 22 12%
Unknown 36 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2019.
All research outputs
#1,224,655
of 19,118,428 outputs
Outputs from Head & Face Medicine
#2
of 302 outputs
Outputs of similar age
#28,281
of 388,102 outputs
Outputs of similar age from Head & Face Medicine
#1
of 39 outputs
Altmetric has tracked 19,118,428 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 302 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 388,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.