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Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16

Overview of attention for article published in Molecular Cancer, April 2015
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2 tweeters

Citations

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272 Dimensions

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72 Mendeley
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Title
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16
Published in
Molecular Cancer, April 2015
DOI 10.1186/s12943-015-0355-8
Pubmed ID
Authors

Rong Kong, Er-bao Zhang, Dan-dan Yin, Liang-hui You, Tong-peng Xu, Wen-ming Chen, Rui Xia, Li Wan, Ming Sun, Zhao-xia Wang, Wei De, Zhi-hong Zhang

Abstract

Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the overall biological role and clinical significance of PVT1 in gastric carcinogenesis remains largely unknown. Expression of PVT1 was analyzed in 80 GC tissues and cell lines by qRT-PCR. The effect of PVT1 on proliferation was evaluated by MTT and colony formation assays, and cell apoptosis was evaluated by Flow-cytometric analysis. GC cells transfected with shPVT1 were injected into nude mice to study the effect of PVT1 on tumorigenesis in vivo. RIP was performed to confirm the interaction between PVT1 and EZH2. ChIP was used to study the promoter region of related genes. The higher expression of PVT1 was significantly correlated with deeper invasion depth and advanced TNM stage. Multivariate analyses revealed that PVT1 expression served as an independent predictor for overall survival (p = 0.031). Further experiments demonstrated that PVT1 knockdown significantly inhibited the proliferation both in vitro and in vivo. Importantly, we also showed that PVT1 played a key role in G1 arrest. Moreover, we further confirmed that PVT1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of p15 and p16. To our knowledge, this is the first report showed that the role and the mechanism of PVT1 in the progression of gastric cancer. Together, these results suggest that lncRNA PVT1 may serve as a candidate prognostic biomarker and target for new therapies in human gastric cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 24%
Student > Ph. D. Student 14 19%
Student > Master 13 18%
Student > Doctoral Student 6 8%
Student > Bachelor 4 6%
Other 5 7%
Unknown 13 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 31 43%
Agricultural and Biological Sciences 10 14%
Medicine and Dentistry 10 14%
Arts and Humanities 2 3%
Immunology and Microbiology 2 3%
Other 4 6%
Unknown 13 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2016.
All research outputs
#9,276,145
of 11,596,660 outputs
Outputs from Molecular Cancer
#707
of 980 outputs
Outputs of similar age
#229,211
of 332,585 outputs
Outputs of similar age from Molecular Cancer
#28
of 50 outputs
Altmetric has tracked 11,596,660 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 980 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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