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Mendeley readers
Attention Score in Context
| Title |
The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia
|
|---|---|
| Published in |
BMC Neurology, January 2016
|
| DOI | 10.1186/s12883-016-0529-z |
| Pubmed ID | |
| Authors |
Ji Eun Lee, Da Un Jeong, Jihyeon Lee, Won Seok Chang, Jin Woo Chang |
| Abstract |
Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes in neurotransmitter systems and spatial memory caused by stimulation of nucleus basalis magnocellularis in a rat model of dementia. We divided rats into four groups: Normal, Lesion, Implantation, and Stimulation. We used 192 IgG-saporin for degeneration of basal forebrain cholinergic neuron related with learning and memory and it was injected into all rats except for the normal group. An electrode was ipsilaterally inserted in the nucleus basalis magnocellularis of all rats of the implantation and stimulation group, and the stimulation group received the electrical stimulation. Features were verified by the Morris water maze, immunochemistry and western blotting. All groups showed similar performances during Morris water maze training. During the probe trial, performance of the lesion and implantation group decreased. However, the stimulation group showed an equivalent performance to the normal group. In the lesion and implantation group, expression of glutamate acid decarboxylase65&67 decreased in the medial prefrontal cortex and expression of glutamate transporters increased in the medial prefrontal cortex and hippocampus. However, expression of the stimulation group showed similar levels as the normal group. The results suggest that nucleus basalis magnocellularis stimulation enhances consolidation and retrieval of visuospatial memory related to changes of glutamate acid decarboxylase65&67 and glutamate transporter. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 14% |
| Researcher | 7 | 14% |
| Student > Master | 4 | 8% |
| Student > Bachelor | 4 | 8% |
| Professor | 3 | 6% |
| Other | 14 | 29% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 20% |
| Medicine and Dentistry | 8 | 16% |
| Agricultural and Biological Sciences | 4 | 8% |
| Psychology | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 14 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#4,181,804
of 22,840,638 outputs
Outputs from BMC Neurology
#493
of 2,437 outputs
Outputs of similar age
#72,614
of 395,131 outputs
Outputs of similar age from BMC Neurology
#11
of 39 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,437 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,131 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.