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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

Overview of attention for article published in Journal of Neuroinflammation, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
1 news outlet

Citations

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44 Dimensions

Readers on

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63 Mendeley
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Title
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
Published in
Journal of Neuroinflammation, January 2016
DOI 10.1186/s12974-015-0470-x
Pubmed ID
Authors

Andrea F. N. Rosenberger, Tjado H. J. Morrema, Wouter H. Gerritsen, Elise S. van Haastert, Hripsime Snkhchyan, Riet Hilhorst, Annemieke J. M. Rozemuller, Philip Scheltens, Saskia M. van der Vies, Jeroen J. M. Hoozemans

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease. In addition to the occurrence of amyloid deposits and widespread tau pathology, AD is associated with a neuroinflammatory response characterized by the activation of microglia and astrocytes. Protein kinase 2 (CK2, former casein kinase II) is involved in a wide variety of cellular processes. Previous studies on CK2 in AD showed controversial results, and the involvement of CK2 in neuroinflammation in AD remains elusive. In this study, we used immunohistochemical and immunofluorescent staining methods to investigate the localization of CK2 in the hippocampus and temporal cortex of patients with AD and non-demented controls. We compared protein levels with Western blotting analysis, and we investigated CK2 activity in human U373 astrocytoma cells and human primary adult astrocytes stimulated with IL-1β or TNF-α. We report increased levels of CK2 in the hippocampus and temporal cortex of AD patients compared to non-demented controls. Immunohistochemical analysis shows CK2 immunoreactivity in astrocytes in AD and control cases. In AD, the presence of CK2 immunoreactive astrocytes is increased. CK2 immunopositive astrocytes are associated with amyloid deposits, suggesting an involvement of CK2 in the neuroinflammatory response. In U373 cells and human primary astrocytes, the selective CK2 inhibitor CX-4945 shows a dose-dependent reduction of the IL-1β or TNF-α induced MCP-1 and IL-6 secretion. This data suggests that CK2 in astrocytes is involved in the neuroinflammatory response in AD. The reduction in pro-inflammatory cytokine secretion by human astrocytes using the selective CK2 inhibitor CX-4945 indicates that CK2 could be a potential target to modulate neuroinflammation in AD.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 21%
Student > Ph. D. Student 12 19%
Student > Bachelor 9 14%
Researcher 7 11%
Student > Postgraduate 3 5%
Other 11 17%
Unknown 8 13%
Readers by discipline Count As %
Neuroscience 18 29%
Biochemistry, Genetics and Molecular Biology 13 21%
Medicine and Dentistry 8 13%
Agricultural and Biological Sciences 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 5 8%
Unknown 11 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2016.
All research outputs
#934,416
of 6,977,329 outputs
Outputs from Journal of Neuroinflammation
#164
of 922 outputs
Outputs of similar age
#53,684
of 306,138 outputs
Outputs of similar age from Journal of Neuroinflammation
#17
of 72 outputs
Altmetric has tracked 6,977,329 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 922 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,138 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.