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MicroRNA-mediated susceptible poplar gene expression regulation associated with the infection of virulent Melampsora larici-populina

Overview of attention for article published in BMC Genomics, January 2016
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Title
MicroRNA-mediated susceptible poplar gene expression regulation associated with the infection of virulent Melampsora larici-populina
Published in
BMC Genomics, January 2016
DOI 10.1186/s12864-015-2286-6
Pubmed ID
Authors

Danlei Li, Feng Wang, Chao Wang, Li Zou, Zhiying Wang, Qiaoli Chen, Chunyang Niu, Ruizhi Zhang, Yaming Ling, Bowen Wang

Abstract

Rust caused by Melampsora larici-populina is one of the most damaging diseases of poplars. Rust is considered to be a model pathogen for genetic studies because both pathogen and host genomes are available. The poplar 'Robusta', whose general rust resistance is defeated by virulent rust E4, provides suitable host material for studies of the gene regulation involved in rust resistance/susceptibility. In this study, we investigated the microRNA-mediated susceptible poplar gene expression regulation associated with the infection of virulent rust. We were particularly interested in delineating the host-pathogen interactions with a specific focus on microRNAs (miRNAs). To study the susceptibility of poplar to M. larici-populina, small RNA (sRNA) libraries, a degradome cDNA library and digital gene expression libraries were constructed for rust-inoculated and rust-free susceptible poplar 'Robusta' leaves through high-throughput sequencing. Altogether, 12,722 regulating interactions were identified. The results delineated the framework of post-transcriptional regulation of gene expression in the susceptible poplar, which was infected by the virulent rust. The results indicated that pathogen-associated molecular patterns (PAMPs) and PAMP-triggered immunity were induced by the infection of virulent rust E4 and that miRNAs still functioned at this stage. After this stage, miRNA-regulated R genes, such as TIR-NBS-LRR and CC-NBS-LRR, were not fully functional. Additionally, the rust-responsive miRNAs did not regulate the signaling component genes related to the salicylic acid pathway or the hypersensitive response. We found that the defense-related post-transcriptional regulation of the susceptible poplar 'Robusta' functions normally only at the stage of PAMPs and PAMP-triggered immunity (PTI). More importantly, the miRNA-mediated post-transcriptional regulation of defense signal pathway genes were inactivated by the infection of virulent rust at the stage of effector-triggered susceptibility and during the following stages of salicylic acid and hypersensitive responses. This inactivation was the major characteristic of 'Robusta' susceptibility.

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Researcher 4 16%
Student > Bachelor 4 16%
Student > Master 3 12%
Other 2 8%
Other 2 8%
Unknown 4 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 52%
Biochemistry, Genetics and Molecular Biology 6 24%
Environmental Science 1 4%
Unknown 5 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2016.
All research outputs
#4,968,130
of 6,982,524 outputs
Outputs from BMC Genomics
#4,010
of 5,295 outputs
Outputs of similar age
#196,384
of 313,382 outputs
Outputs of similar age from BMC Genomics
#218
of 259 outputs
Altmetric has tracked 6,982,524 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,295 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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