↓ Skip to main content

Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway

Overview of attention for article published in Clinical and Translational Allergy, January 2016
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

twitter
6 tweeters
facebook
3 Facebook pages
video
1 video uploader

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
33 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway
Published in
Clinical and Translational Allergy, January 2016
DOI 10.1186/s13601-016-0090-2
Pubmed ID
Authors

Christophe P. Frossard, Simone C. Zimmerli, José M. Rincon Garriz, Philippe A. Eigenmann

Abstract

Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce. We explored the role of TSLP in a mouse model with oral sensitization and oral challenge eliciting food allergy. TSLP receptor (TSLPR)-/- mice and wild type mice were orally sensitized to β-lactoglobulin in presence of cholera toxin (CT) or CT alone. The elicited immune response was characterized in vitro and the mice were subsequently challenged with the antigen. Lymphocytes from various locations in the gut were activated either by the antigen or by CT and assayed for cytokine secretion. Here we report that TSLPR-/- are less prone to generate food-induced reactions in conjunction with a decreased antigen-specific IgG1, but not IgE response. In addition, mesenteric lymphnode lymphocytes of TSLPR-/- mice were secreting lower quantities of IL-4, IL-5 and IL-10 after in vivo Ag activation, whereas higher numbers of IL-17 secreting cells were observed. Similarly, activation by the Th2-type adjuvant cholera toxin resulted in an increased frequency of IL-12 and IL-17 secreting lamina propria and mesenteric lymphocytes, together with increased production of IL-12 by activated dendritic cells in TSLPR-/- mice. TSLP can be considered as an essential, but not exclusive, mediator for elicitation of food allergy in mice, as well as a potential target for future therapeutic interventions.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 21%
Student > Ph. D. Student 6 18%
Student > Bachelor 5 15%
Professor > Associate Professor 3 9%
Student > Master 2 6%
Other 3 9%
Unknown 7 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 27%
Immunology and Microbiology 6 18%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Medicine and Dentistry 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 2 6%
Unknown 8 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2016.
All research outputs
#3,221,615
of 12,657,345 outputs
Outputs from Clinical and Translational Allergy
#205
of 385 outputs
Outputs of similar age
#83,394
of 331,807 outputs
Outputs of similar age from Clinical and Translational Allergy
#1
of 1 outputs
Altmetric has tracked 12,657,345 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 385 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,807 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them