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Occult hepatitis B virus infection: influence of S protein variants

Overview of attention for article published in Virology Journal, January 2016
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Title
Occult hepatitis B virus infection: influence of S protein variants
Published in
Virology Journal, January 2016
DOI 10.1186/s12985-016-0464-z
Pubmed ID
Authors

Zhenhua Zhang, Ling Zhang, Yu Dai, Yafei Zhang, Jun Li, Xu Li

Abstract

In occult hepatitis B viral infection (OBI), the persistence of hepatitis B virus (HBV) DNA is associated with a lack of hepatitis B surface antigen (HBsAg). To assess the possible role of HBsAg immune escape variants in OBI patients, variability in the HBV S gene was evaluated for OBI patients as well as chronic HBV infection patients from the same families. We selected 17 HBV DNA-positive/HBsAg-negative patients (OBI group) and 15 HBV DNA- and HBsAg-positive patients from OBI families (control group). The S gene was amplified and cloned, and at least 15 clones per patient were sequenced and analyzed. Although the incidence of stop codon mutations within the S region was higher in the OBI group (13.6 %) than in the control group (1.5 %, P < 0.001), this type of mutation, together with insertion and deletion mutations, was prevalent in only three OBI patients. In the major hydrophilic region (MHR), a median of 0.75 residues were altered in every 100 residues for the OBI patients, whereas 0.95 out of 100 residues were changed in the control group (P = 0.428). Furthermore, some variants that are generally considered immune escape variants, such as mutations at positions s145, s147, and s123, were only observed in less than 5 % of all the clones sequenced, in either OBI or control group. Our data suggest that HBsAg variants may not play a major role in OBI pathogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Student > Master 5 17%
Student > Bachelor 2 7%
Student > Postgraduate 2 7%
Lecturer 1 3%
Other 3 10%
Unknown 12 40%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 6 20%
Immunology and Microbiology 3 10%
Agricultural and Biological Sciences 2 7%
Economics, Econometrics and Finance 1 3%
Other 1 3%
Unknown 11 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2016.
All research outputs
#15,354,849
of 22,840,638 outputs
Outputs from Virology Journal
#1,961
of 3,046 outputs
Outputs of similar age
#231,735
of 394,468 outputs
Outputs of similar age from Virology Journal
#27
of 43 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,046 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,468 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.