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Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study

Overview of attention for article published in Clinical and Translational Allergy, January 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 733)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
11 news outlets
blogs
1 blog
policy
2 policy sources
twitter
49 X users
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5 Facebook pages

Citations

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81 Dimensions

Readers on

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180 Mendeley
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Title
Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study
Published in
Clinical and Translational Allergy, January 2016
DOI 10.1186/s13601-016-0089-8
Pubmed ID
Authors

Kate E. C. Grimshaw, Trevor Bryant, Erin M. Oliver, Jane Martin, Joe Maskell, Terri Kemp, E. N. Clare Mills, Keith D. Foote, Barrie M. Margetts, Kirsten Beyer, Graham Roberts

Abstract

The prevalence of food hypersensitivity in the UK is still largely open to debate. Additionally its pathogenesis is also unclear although it is known that there are differing phenotypes. Determining its prevalence, along with identifying those factors associated with its development will help to assess its clinical importance within the national setting and also add to the debate on appropriate prevention strategies. A population based birth cohort study conducted in Hampshire, UK as part of the EuroPrevall birth cohort study. 1140 infants were recruited with 823 being followed up until 2 years of age. Infants with suspected food reactions were assessed including specific IgE measurement and skin prick testing. Diagnosis of food hypersensitivity was by positive double-blind, placebo-controlled food challenge (DBPCFC) where symptoms up to 48 h after the end of the food challenge were considered indicative of a food hypersensitivity. Factors associated with food hypersensitivity and its two phenotypes of IgE-mediated and non-IgE-mediated disease were modelled in a multivariable logistic regression analysis. Cumulative incidence of food hypersensitivity by 2 years of age was 5.0 %. The cumulative incidence for individual food allergens were hens' egg 2.7 % (1.6-3.8); cows' milk 2.4 % (1.4-3.5); peanut 0.7 % (0.1-1.3); soy 0.4 % (0.0-0.8); wheat 0.2 % (0.0-0.5) and 0.1 % (0.0-0.32) for fish. The cumulative incidence of IgE-mediated food allergy was 2.6 % with 2.1 % reacting to hens' egg. For non-IgE-mediated food allergy the cumulative incidence was 2.4 % (cows' milk 1.7 %). Predictors for any food hypersensitivity were wheeze, maternal atopy, increasing gestational age, age at first solid food introduction and mean healthy dietary pattern score. Predictors for IgE mediated allergy were eczema, rhinitis and healthy dietary pattern score whereas for non-IgE-mediated food allergy the predictors were dog in the home, healthy dietary pattern score, maternal consumption of probiotics during breastfeeding and age at first solid food introduction. Just under half the infants with confirmed food hypersensitivity had no demonstrable IgE. In an exploratory analysis, risk factors for this phenotype of food hypersensitivity differed from those for IgE-mediated food allergy except for a healthy infant diet which was associated with less risk for both phenotypes.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 179 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 33 18%
Student > Bachelor 20 11%
Student > Ph. D. Student 17 9%
Researcher 16 9%
Other 14 8%
Other 38 21%
Unknown 42 23%
Readers by discipline Count As %
Medicine and Dentistry 60 33%
Agricultural and Biological Sciences 22 12%
Nursing and Health Professions 19 11%
Immunology and Microbiology 9 5%
Biochemistry, Genetics and Molecular Biology 8 4%
Other 18 10%
Unknown 44 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 118. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2022.
All research outputs
#341,929
of 24,835,287 outputs
Outputs from Clinical and Translational Allergy
#9
of 733 outputs
Outputs of similar age
#6,251
of 407,774 outputs
Outputs of similar age from Clinical and Translational Allergy
#2
of 12 outputs
Altmetric has tracked 24,835,287 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 733 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 407,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.