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Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior

Overview of attention for article published in Head & Face Medicine, January 2016
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Title
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior
Published in
Head & Face Medicine, January 2016
DOI 10.1186/s13005-016-0102-4
Pubmed ID
Authors

Nada Binmadi, Azza Elsissi, Nadia Elsissi

Abstract

The most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the most common site in which this tumor arises. CD44, a trans-membrane glycoprotein, is an adhesion molecule of cell surface that play a role in the connections between cell-cell and cell-matrix. Many malignant tumors express high levels of CD44, thus, CD44 may be used as an indicator of aggressive behavior of some human malignancy. We evaluate CD44 expression in different grades of mucoepidermoid carcinoma and determine whether expression of CD44 can be used to predict tumor aggressiveness. Fifteen cases of mucoepidermoid carcinoma were retrieved from the oral pathology archives and grouped according to the histological grade as well as the clinical behavior regarding metastases and/or recurrence. Tissue sections were immunohistochemically stained for CD44. CD44 staining was scored for intensity and proportion of cells stained. A higher proportion of high-grade tumor tissues showed moderate or strong CD44 staining compared to low-grade tumors. Additionally, CD44 expression was stronger in tumors from patients with recurrences or metastases, but theses differences were not statistically significant. Our result showed that mucoepidermoid carcinomas are immunohistochemistry positive to CD44 compare to normal. A trend of CD44 expression associated with different histological grading and aggressive behavior of this tumor.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 20%
Student > Doctoral Student 2 13%
Student > Bachelor 2 13%
Student > Master 2 13%
Student > Ph. D. Student 1 7%
Other 4 27%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 9 60%
Psychology 1 7%
Nursing and Health Professions 1 7%
Unknown 4 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2016.
All research outputs
#5,467,794
of 7,252,957 outputs
Outputs from Head & Face Medicine
#105
of 198 outputs
Outputs of similar age
#222,930
of 321,706 outputs
Outputs of similar age from Head & Face Medicine
#10
of 13 outputs
Altmetric has tracked 7,252,957 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 198 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,706 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.