Title |
Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis
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Published in |
BMC Cardiovascular Disorders, January 2016
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DOI | 10.1186/s12872-016-0198-2 |
Pubmed ID | |
Authors |
Meng-Die Chen, Si-Si Dong, Ning-Yu Cai, Meng-Di Fan, Su-Ping Gu, Jin-Jue Zheng, Hai-Min Yin, Xin-He Zhou, Liang-Xue Wang, Chun-Ying Li, Chao Zheng |
Abstract |
The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM). We conducted a comprehensive search for controlled studies that evaluated the efficacy and safety of MRAs in patients with DM and HF. Medline, Embase and Cochrane databases were searched. Two reviewers independently identified citations, extracted data and evaluated quality. Risk estimations were abstracted and pooled where appropriate. Four observational studies were included. MRAs use was associated with reduced mortality compared with controls (RR = 0.78; 95 % CI: 0.69-0.88; I (2) = 0 %; P < 0.001). Increased risk of developing hyperkalaemia was observed in those patients taking MRAs (RR = 1.74; 95 % CI: 1.27-2.38; I (2) = 0 %; P = 0.0005). The current cumulative evidence suggests that MRAs can improve clinical outcomes but increase the risk of hyperkalaemia in patients with DM and HF. PROSPERO CRD42015025690 . |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 13% |
Other | 4 | 11% |
Student > Bachelor | 4 | 11% |
Researcher | 4 | 11% |
Professor | 2 | 5% |
Other | 7 | 18% |
Unknown | 12 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 47% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 5% |
Unknown | 13 | 34% |