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Prevalence and clinical impact of magnesium disorders in end-stage renal disease: a protocol for a systematic review

Overview of attention for article published in Systematic Reviews, May 2015
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Title
Prevalence and clinical impact of magnesium disorders in end-stage renal disease: a protocol for a systematic review
Published in
Systematic Reviews, May 2015
DOI 10.1186/s13643-015-0063-x
Pubmed ID
Authors

John Floridis, Asanga Abeyaratne, Sandawana William Majoni

Abstract

Magnesium plays a key role in maintaining internal homeostasis through actions in the musculoskeletal, nervous, endocrine and cellular messenger systems. Renal excretion is the major route of magnesium elimination from the body. A positive magnesium balance would be expected in renal failure. However, a compensatory decrease in tubular reabsorption is expected to operate to maintain adequate urinary magnesium excretion even when glomerular filtration rate is very low. Patients with end-stage renal disease and those on dialysis have impaired regulatory mechanisms, predisposing them to disturbances in magnesium levels. The effects of high or low magnesium can have deleterious health outcomes, which impact on the co-morbidities and outcomes of chronic renal disease. This systematic review aims to determine the prevalence and clinical outcomes of magnesium disorders in end-stage renal disease. We will undertake a comprehensive search of various databases, MEDLINE, PubMED, EMBASE, Cochrane Library, Cochrane Collaboration, CIHNAL (Ebsco), Web of Science and Google Scholar, for observational studies and clinical trials on magnesium disorders in end-stage renal disease using key terms to identify papers for inclusion. Paper selection and data extraction (where appropriate) will be performed in duplicate on socio-demographic characteristics of participants, diagnosis of end-stage renal disease, magnesium levels, prevalence and clinical outcomes. An assessment of quality will be performed using a modified Newcastle-Ottawa Scale (NOS), including identification of any bias, which may influence findings. Data will be pooled together according to whether the studies were on pre-dialysis, hemodialysis or peritoneal dialysis participants. References from individual papers will also be screened as appropriate. Paper organisation and data extraction and analysis will take place using Microsoft Excel® and Stata version 13®. This systematic review will represent a significant effort at pooling together information on prevalence and outcomes of magnesium disturbances amongst end-stage renal disease patients, which may guide further research and management of the disorders. PROSPERO: CRD42014014354.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 21%
Student > Postgraduate 4 12%
Student > Ph. D. Student 4 12%
Student > Doctoral Student 2 6%
Student > Bachelor 2 6%
Other 7 21%
Unknown 8 24%
Readers by discipline Count As %
Medicine and Dentistry 12 35%
Nursing and Health Professions 5 15%
Social Sciences 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Agricultural and Biological Sciences 1 3%
Other 4 12%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2016.
All research outputs
#17,783,561
of 22,842,950 outputs
Outputs from Systematic Reviews
#1,705
of 1,999 outputs
Outputs of similar age
#179,886
of 266,699 outputs
Outputs of similar age from Systematic Reviews
#31
of 37 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,999 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.