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Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

Overview of attention for article published in BMC Medicine, February 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
11 news outlets
blogs
2 blogs
twitter
223 X users
facebook
3 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
415 Dimensions

Readers on

mendeley
601 Mendeley
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Title
Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature
Published in
BMC Medicine, February 2016
DOI 10.1186/s12916-016-0553-2
Pubmed ID
Authors

Igho J. Onakpoya, Carl J. Heneghan, Jeffrey K. Aronson

Abstract

There have been no studies of the patterns of post-marketing withdrawals of medicinal products to which adverse reactions have been attributed. We identified medicinal products that were withdrawn because of adverse drug reactions, examined the evidence to support such withdrawals, and explored the pattern of withdrawals across countries. We searched PubMed, Google Scholar, the WHO's database of drugs, the websites of drug regulatory authorities, and textbooks. We included medicinal products withdrawn between 1950 and 2014 and assessed the levels of evidence used in making withdrawal decisions using the criteria of the Oxford Centre for Evidence Based Medicine. We identified 462 medicinal products that were withdrawn from the market between 1953 and 2013, the most common reason being hepatotoxicity. The supporting evidence in 72 % of cases consisted of anecdotal reports. Only 43 (9.34 %) drugs were withdrawn worldwide and 179 (39 %) were withdrawn in one country only. Withdrawal was significantly less likely in Africa than in other continents (Europe, the Americas, Asia, and Australasia and Oceania). The median interval between the first reported adverse reaction and the year of first withdrawal was 6 years (IQR, 1-15) and the interval did not consistently shorten over time. There are discrepancies in the patterns of withdrawal of medicinal products from the market when adverse reactions are suspected, and withdrawals are inconsistent across countries. Greater co-ordination among drug regulatory authorities and increased transparency in reporting suspected adverse drug reactions would help improve current decision-making processes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 223 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 601 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
Germany 1 <1%
South Africa 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Finland 1 <1%
Unknown 594 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 100 17%
Researcher 91 15%
Student > Master 79 13%
Student > Bachelor 74 12%
Other 33 5%
Other 84 14%
Unknown 140 23%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 122 20%
Medicine and Dentistry 99 16%
Biochemistry, Genetics and Molecular Biology 72 12%
Agricultural and Biological Sciences 38 6%
Engineering 23 4%
Other 84 14%
Unknown 163 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 249. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2024.
All research outputs
#149,841
of 25,547,324 outputs
Outputs from BMC Medicine
#134
of 4,045 outputs
Outputs of similar age
#2,561
of 406,643 outputs
Outputs of similar age from BMC Medicine
#1
of 41 outputs
Altmetric has tracked 25,547,324 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,045 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.