↓ Skip to main content

Cu/Zn superoxide dismutase expression in the postnatal rat brain following an excitotoxic injury

Overview of attention for article published in Journal of Neuroinflammation, June 2005
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
32 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cu/Zn superoxide dismutase expression in the postnatal rat brain following an excitotoxic injury
Published in
Journal of Neuroinflammation, June 2005
DOI 10.1186/1742-2094-2-12
Pubmed ID
Authors

Hugo Peluffo, Laia Acarin, Maryam Faiz, Bernardo Castellano, Berta Gonzalez

Abstract

BACKGROUND: In the nervous system, as in other organs, Cu/Zn superoxide dismutase (Cu/Zn SOD) is a key antioxidant enzyme involved in superoxide detoxification in normal cellular metabolism and after cell injury. Although it has been suggested that immature brain has a different susceptibility to oxidative damage than adult brain, the distribution and cell-specific expression of this enzyme in immature brain and after postnatal brain damage has not been documented. METHODS: In this study, we used immunohistochemistry and western blot to analyze the expression of Cu/Zn SOD in intact immature rat brain and in immature rat brain after an NMDA-induced excitotoxic cortical injury performed at postnatal day 9. Double immunofluorescence labelling was used to identify Cu/Zn SOD-expressing cell populations. RESULTS: In intact immature brain, Cu/Zn SOD enzyme was widely expressed at high levels in neurons mainly located in cortical layers II, III and V, in the sub-plate, in the pyriform cortex, in the hippocampus, and in the hypothalamus. Glial fibrillary acidic protein-positive cells only showed Cu/Zn SOD expression in the glia limitans and in scattered cells of the ventricle walls. No expression was detected in interfascicular oligodendroglia, microglia or endothelial cells. Following excitotoxic damage, neuronal Cu/Zn SOD was rapidly downregulated (over 2-4 hours) at the injection site before neurodegeneration signals and TUNEL staining were observed. Later, from 1 day post-lesion onward, an upregulation of Cu/Zn SOD was found due to increased expression in astroglia. A further increase was observed at 3, 5 and 7 days that corresponded to extensive induction of Cu/Zn SOD in highly reactive astrocytes and in the astroglial scar. CONCLUSION: We show here that, in the intact immature brain, the expression of Cu/Zn SOD was mainly found in neurons. When damage occurs, a strong and very rapid downregulation of this enzyme precedes neuronal degeneration, and is followed by an upregulation of Cu/Zn SOD in astroglial cells.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 6%
United States 1 3%
Italy 1 3%
Unknown 28 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 25%
Student > Ph. D. Student 6 19%
Student > Master 6 19%
Professor 2 6%
Professor > Associate Professor 2 6%
Other 5 16%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 44%
Medicine and Dentistry 6 19%
Neuroscience 3 9%
Environmental Science 1 3%
Psychology 1 3%
Other 3 9%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2011.
All research outputs
#5,580,292
of 19,960,113 outputs
Outputs from Journal of Neuroinflammation
#962
of 2,340 outputs
Outputs of similar age
#59,048
of 241,843 outputs
Outputs of similar age from Journal of Neuroinflammation
#15
of 52 outputs
Altmetric has tracked 19,960,113 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,340 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,843 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.