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Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats

Overview of attention for article published in Nutrition & Metabolism, February 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
5 news outlets
twitter
48 tweeters
patent
3 patents
facebook
20 Facebook pages
wikipedia
1 Wikipedia page
video
2 video uploaders

Citations

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85 Dimensions

Readers on

mendeley
214 Mendeley
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Title
Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats
Published in
Nutrition & Metabolism, February 2016
DOI 10.1186/s12986-016-0069-y
Pubmed ID
Authors

Shannon L. Kesl, Angela M. Poff, Nathan P. Ward, Tina N. Fiorelli, Csilla Ari, Ashley J. Van Putten, Jacob W. Sherwood, Patrick Arnold, Dominic P. D’Agostino

Abstract

Nutritional ketosis induced by the ketogenic diet (KD) has therapeutic applications for many disease states. We hypothesized that oral administration of exogenous ketone supplements could produce sustained nutritional ketosis (>0.5 mM) without carbohydrate restriction. We tested the effects of 28-day administration of five ketone supplements on blood glucose, ketones, and lipids in male Sprague-Dawley rats. The supplements included: 1,3-butanediol (BD), a sodium/potassium β-hydroxybutyrate (βHB) mineral salt (BMS), medium chain triglyceride oil (MCT), BMS + MCT 1:1 mixture, and 1,3 butanediol acetoacetate diester (KE). Rats received a daily 5-10 g/kg dose of their respective ketone supplement via intragastric gavage during treatment. Weekly whole blood samples were taken for analysis of glucose and βHB at baseline and, 0.5, 1, 4, 8, and 12 h post-gavage, or until βHB returned to baseline. At 28 days, triglycerides, total cholesterol and high-density lipoprotein (HDL) were measured. Exogenous ketone supplementation caused a rapid and sustained elevation of βHB, reduction of glucose, and little change to lipid biomarkers compared to control animals. This study demonstrates the efficacy and tolerability of oral exogenous ketone supplementation in inducing nutritional ketosis independent of dietary restriction.

Twitter Demographics

The data shown below were collected from the profiles of 48 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 213 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 45 21%
Student > Bachelor 33 15%
Researcher 28 13%
Student > Ph. D. Student 20 9%
Other 14 7%
Other 39 18%
Unknown 35 16%
Readers by discipline Count As %
Medicine and Dentistry 32 15%
Agricultural and Biological Sciences 30 14%
Biochemistry, Genetics and Molecular Biology 28 13%
Neuroscience 18 8%
Nursing and Health Professions 17 8%
Other 47 22%
Unknown 42 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 86. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2021.
All research outputs
#341,606
of 20,027,474 outputs
Outputs from Nutrition & Metabolism
#57
of 883 outputs
Outputs of similar age
#7,725
of 365,957 outputs
Outputs of similar age from Nutrition & Metabolism
#1
of 1 outputs
Altmetric has tracked 20,027,474 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 883 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them