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From competency to dormancy: a 3D model to study cancer cells and drug responsiveness

Overview of attention for article published in Journal of Translational Medicine, February 2016
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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2 X users

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73 Mendeley
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Title
From competency to dormancy: a 3D model to study cancer cells and drug responsiveness
Published in
Journal of Translational Medicine, February 2016
DOI 10.1186/s12967-016-0798-8
Pubmed ID
Authors

Josephine Y. Fang, Shih-Jye Tan, Yi-Chen Wu, Zhi Yang, Ba X. Hoang, Bo Han

Abstract

The heterogeneous and dynamic tumor microenvironment has significant impact on cancer cell proliferation, invasion, drug response, and is probably associated with entering dormancy and recurrence. However, these complex settings are hard to recapitulate in vitro. In this study, we mimic different restriction forces that tumor cells are exposed to using a physiologically relevant 3D model with tunable mechanical stiffness. Breast cancer MDA-MB-231, colon cancer HCT-116 and pancreatic cancer CFPAC cells embedded in the stiffer gels exhibit a changed morphology and cluster formation, prolonged doubling time, and a slower metabolism rate, recapitulating the pathway from competency to dormancy. Altering environmental restriction allows them to re-enter and exit dormant conditions and change their sensitivities to drugs such as paclitaxol and gemcitabine. Cells surviving drug treatments can still regain competent growth and form tumors in vivo. We have successfully developed an in vitro 3D model to mimic the effects of matrix restriction on tumor cells and this high throughput model can be used to study tumor cellular functions and their drug responses in their different states. This all in one platform may aid effective drug development.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 26%
Student > Master 9 12%
Student > Bachelor 8 11%
Researcher 7 10%
Student > Doctoral Student 5 7%
Other 6 8%
Unknown 19 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 25%
Engineering 9 12%
Agricultural and Biological Sciences 7 10%
Medicine and Dentistry 5 7%
Immunology and Microbiology 3 4%
Other 7 10%
Unknown 24 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#14,246,461
of 22,842,950 outputs
Outputs from Journal of Translational Medicine
#1,783
of 3,997 outputs
Outputs of similar age
#208,228
of 397,006 outputs
Outputs of similar age from Journal of Translational Medicine
#28
of 78 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,997 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,006 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.