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Involved-field radiotherapy for esophageal squamous cell carcinoma: theory and practice

Overview of attention for article published in Radiation Oncology, February 2016
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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Citations

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39 Dimensions

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52 Mendeley
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Title
Involved-field radiotherapy for esophageal squamous cell carcinoma: theory and practice
Published in
Radiation Oncology, February 2016
DOI 10.1186/s13014-016-0589-7
Pubmed ID
Authors

Minghuan Li, Xiaoli Zhang, Fen Zhao, Yijun Luo, Li Kong, Jinming Yu

Abstract

Esophageal carcinoma (EC) is characterized by a high rate of lymph node metastasis and its spread pattern is not always predictable. Chemoradiotherapy has an important role in the treatment of EC in both the inoperable and the pre-operative settings. However, regarding the target volume for radiation, different clinical practices exist. Theoretically, in addition to the clinical target volume administered to the gross lesion, it might seem logical to deliver a certain dose to the uninvolved regional lymph node area at risk for microscopic disease. However, in practice, it is difficult because of the intolerance of normal tissue to radiotherapy (RT), particularly if all regions containing the cervical, mediastinal, and upper abdominal nodes are covered. To date, the use of elective nodal irradiation (ENI) is still controversial in the field of radiotherapy. Some investigators use involved-field radiotherapy (IFRT) in order to reduce treatment-related toxicities. It is thought that micrometastases can be controlled, to some extent, by chemotherapy and the abscopal effects of radiation. It is the presence of overtly involved lymph nodes rather than the micrometastatic nodes negatively affects survival in patients with EC. In another hand, lymph nodes stationed near primary tumors also receive considerable incidental irradiation doses that may contribute to the elimination of subclinical lesions. These data indicate that an irradiation volume covering only the gross tumor is appropriate. When using ENI or IFRT, very few patients experience solitary regional node failure and out-of-field lymph node failure is not common. Primary tumor recurrence and distant metastases, rather than regional lymph node failure, affect the overall survival in patients with EC. The available evidence indicates that the use of ENI seems to prevent or delay regional nodal relapse rather than improve survival. In a word, these data suggest that IFRT is feasible in EC patients.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Master 7 13%
Student > Bachelor 6 12%
Student > Doctoral Student 6 12%
Student > Ph. D. Student 6 12%
Other 7 13%
Unknown 10 19%
Readers by discipline Count As %
Medicine and Dentistry 24 46%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Nursing and Health Professions 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Psychology 2 4%
Other 2 4%
Unknown 16 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2016.
All research outputs
#13,092,947
of 22,844,985 outputs
Outputs from Radiation Oncology
#586
of 2,057 outputs
Outputs of similar age
#184,265
of 397,234 outputs
Outputs of similar age from Radiation Oncology
#9
of 50 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,057 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,234 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.