Title |
Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis
|
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Published in |
Arthritis Research & Therapy, December 2009
|
DOI | 10.1186/ar2897 |
Pubmed ID | |
Authors |
Laure Delavallée, Luca Semerano, Eric Assier, Géraldine Vogel, Grégoire Vuagniaux, Marion Laborie, Daniel Zagury, Natacha Bessis, Marie-Christophe Boissier |
Abstract |
Passive blockade of tumor necrosis factor-alpha (TNF-alpha) has demonstrated high therapeutic efficiency in chronic inflammatory diseases, such as rheumatoid arthritis, although some concerns remain such as occurrence of resistance and high cost. These limitations prompted investigations of an alternative strategy to target TNF-alpha. This study sought to demonstrate a long-lasting therapeutic effect on established arthritis of an active immunotherapy to human (h) TNF-alpha and to evaluate the long-term consequences of an endogenous anti-TNF-alpha response. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Norway | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 23% |
Researcher | 7 | 23% |
Professor > Associate Professor | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Other | 2 | 6% |
Other | 3 | 10% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 48% |
Agricultural and Biological Sciences | 7 | 23% |
Computer Science | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 5 | 16% |