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Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis

Overview of attention for article published in Arthritis Research & Therapy, December 2009
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1 research highlight platform

Citations

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Readers on

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31 Mendeley
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Title
Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis
Published in
Arthritis Research & Therapy, December 2009
DOI 10.1186/ar2897
Pubmed ID
Authors

Laure Delavallée, Luca Semerano, Eric Assier, Géraldine Vogel, Grégoire Vuagniaux, Marion Laborie, Daniel Zagury, Natacha Bessis, Marie-Christophe Boissier

Abstract

Passive blockade of tumor necrosis factor-alpha (TNF-alpha) has demonstrated high therapeutic efficiency in chronic inflammatory diseases, such as rheumatoid arthritis, although some concerns remain such as occurrence of resistance and high cost. These limitations prompted investigations of an alternative strategy to target TNF-alpha. This study sought to demonstrate a long-lasting therapeutic effect on established arthritis of an active immunotherapy to human (h) TNF-alpha and to evaluate the long-term consequences of an endogenous anti-TNF-alpha response.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Norway 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 23%
Researcher 7 23%
Professor > Associate Professor 4 13%
Student > Ph. D. Student 3 10%
Other 2 6%
Other 3 10%
Unknown 5 16%
Readers by discipline Count As %
Medicine and Dentistry 15 48%
Agricultural and Biological Sciences 7 23%
Computer Science 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 5 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2010.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,381 outputs
Outputs of similar age
#143,842
of 172,595 outputs
Outputs of similar age from Arthritis Research & Therapy
#15
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,595 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.