Title |
scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
|
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Published in |
BMC Biology, September 2009
|
DOI | 10.1186/1741-7007-7-62 |
Pubmed ID | |
Authors |
Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby |
Abstract |
Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, therefore, a central issue in cancer biology. The Drosophila gene scribble (scrib) encodes a PDZ-domain scaffolding protein that regulates cell polarity and acts as a tumour suppressor in flies. Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations. |
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Student > Ph. D. Student | 24 | 27% |
Student > Bachelor | 7 | 8% |
Professor > Associate Professor | 5 | 6% |
Student > Master | 5 | 6% |
Other | 12 | 13% |
Unknown | 4 | 4% |
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