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scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Overview of attention for article published in BMC Biology, September 2009
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Title
scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
Published in
BMC Biology, September 2009
DOI 10.1186/1741-7007-7-62
Pubmed ID
Authors

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby

Abstract

Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, therefore, a central issue in cancer biology. The Drosophila gene scribble (scrib) encodes a PDZ-domain scaffolding protein that regulates cell polarity and acts as a tumour suppressor in flies. Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
Japan 1 1%
Germany 1 1%
Canada 1 1%
Unknown 82 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 36%
Student > Ph. D. Student 24 27%
Student > Bachelor 7 8%
Professor > Associate Professor 5 6%
Student > Master 5 6%
Other 12 13%
Unknown 4 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 47%
Biochemistry, Genetics and Molecular Biology 31 35%
Medicine and Dentistry 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Decision Sciences 1 1%
Other 3 3%
Unknown 8 9%