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scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Overview of attention for article published in BMC Biology, September 2009
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Citations

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78 Dimensions

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88 Mendeley
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Title
scribblemutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
Published in
BMC Biology, September 2009
DOI 10.1186/1741-7007-7-62
Pubmed ID
Authors

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby

Abstract

Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, therefore, a central issue in cancer biology. The Drosophila gene scribble (scrib) encodes a PDZ-domain scaffolding protein that regulates cell polarity and acts as a tumour suppressor in flies. Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Japan 1 1%
Germany 1 1%
Canada 1 1%
Unknown 81 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 36%
Student > Ph. D. Student 24 27%
Student > Bachelor 7 8%
Professor > Associate Professor 5 6%
Student > Master 5 6%
Other 12 14%
Unknown 3 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 48%
Biochemistry, Genetics and Molecular Biology 31 35%
Medicine and Dentistry 3 3%
Unspecified 1 1%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 4 5%
Unknown 6 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2010.
All research outputs
#7,877,082
of 12,554,200 outputs
Outputs from BMC Biology
#961
of 1,132 outputs
Outputs of similar age
#113,802
of 215,554 outputs
Outputs of similar age from BMC Biology
#64
of 76 outputs
Altmetric has tracked 12,554,200 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,554 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.