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Use of the viral 2A peptide for bicistronic expression in transgenic mice

Overview of attention for article published in BMC Biology, September 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
patent
14 patents
f1000
1 research highlight platform

Citations

dimensions_citation
195 Dimensions

Readers on

mendeley
527 Mendeley
citeulike
2 CiteULike
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Title
Use of the viral 2A peptide for bicistronic expression in transgenic mice
Published in
BMC Biology, September 2008
DOI 10.1186/1741-7007-6-40
Pubmed ID
Authors

Georgios Trichas, Jo Begbie, Shankar Srinivas

Abstract

Transgenic animals are widely used in biomedical research and biotechnology. Multicistronic constructs, in which several proteins are encoded by a single messenger RNA, are commonly used in genetically engineered animals. This is currently done by using an internal ribosomal entry site to separate the different coding regions. 2A peptides result in the co-translational 'cleavage' of proteins and are an attractive alternative to the internal ribosomal entry site. They are more reliable than the internal ribosomal entry site and lead to expression of multiple cistrons at equimolar levels. They work in a wide variety of eukaryotic cells, but to date have not been demonstrated to function in transgenic mice in an inheritable manner.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 527 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 6 1%
United States 6 1%
United Kingdom 3 <1%
Spain 2 <1%
Japan 2 <1%
Belgium 2 <1%
Brazil 1 <1%
Israel 1 <1%
Netherlands 1 <1%
Other 8 2%
Unknown 495 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 136 26%
Student > Ph. D. Student 132 25%
Student > Master 50 9%
Student > Bachelor 41 8%
Professor > Associate Professor 33 6%
Other 83 16%
Unknown 52 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 270 51%
Biochemistry, Genetics and Molecular Biology 104 20%
Medicine and Dentistry 29 6%
Neuroscience 19 4%
Engineering 11 2%
Other 36 7%
Unknown 58 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2023.
All research outputs
#1,766,250
of 23,545,680 outputs
Outputs from BMC Biology
#510
of 2,065 outputs
Outputs of similar age
#4,536
of 88,679 outputs
Outputs of similar age from BMC Biology
#2
of 7 outputs
Altmetric has tracked 23,545,680 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,065 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 88,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.