Title |
Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue
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Published in |
BMC Neuroscience, November 2008
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DOI | 10.1186/1471-2202-9-110 |
Pubmed ID | |
Authors |
Marco Tizzano, Gennady Dvoryanchikov, Jennell K Barrows, Soochong Kim, Nirupa Chaudhari, Thomas E Finger |
Abstract |
"Type II"/Receptor cells express G protein-coupled receptors (GPCRs) for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs), as well as the proteins for downstream signalling cascades. Transduction downstream of T1Rs and T2Rs relies on G-protein and PLCbeta2-mediated release of stored Ca2+. Whereas Galphagus (gustducin) couples to the T2R (bitter) receptors, which Galpha-subunit couples to the sweet (T1R2 + T1R3) receptor is presently not known. We utilized RT-PCR, immunocytochemistry and single-cell gene expression profiling to examine the expression of the Galphaq family (q, 11, 14) in mouse taste buds. |
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