Title |
Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts
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Published in |
Neural Development, January 2011
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DOI | 10.1186/1749-8104-6-1 |
Pubmed ID | |
Authors |
Katherine A Zukor, David T Kent, Shannon J Odelberg |
Abstract |
Newts have the remarkable ability to regenerate their spinal cords as adults. Their spinal cords regenerate with the regenerating tail after tail amputation, as well as after a gap-inducing spinal cord injury (SCI), such as a complete transection. While most studies on newt spinal cord regeneration have focused on events occurring after tail amputation, less attention has been given to events occurring after an SCI, a context that is more relevant to human SCI. Our goal was to use modern labeling and imaging techniques to observe axons regenerating across a complete transection injury and determine how cells and the extracellular matrix in the injury site might contribute to the regenerative process. |
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