A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus.
Molecular Brain, August 2009
Guilding C, Hughes AT, Brown TM, Namvar S, Piggins HD, Clare Guilding, Alun TL Hughes, Timothy M Brown, Sara Namvar, Hugh D Piggins
In mammals, the synchronized activity of cell autonomous clocks in the suprachiasmatic nuclei (SCN) enables this structure to function as the master circadian clock, coordinating daily rhythms in physiology and behavior. However, the dominance of this clock has been challenged by the observations that metabolic duress can over-ride SCN controlled rhythms, and that clock genes are expressed in many brain areas, including those implicated in the regulation of appetite and feeding. The recent development of mice in which clock gene/protein activity is reported by bioluminescent constructs (luciferase or luc) now enables us to track molecular oscillations in numerous tissues ex vivo. Consequently we determined both clock activities and responsiveness to metabolic perturbations of cells and tissues within the mediobasal hypothalamus (MBH), a site pivotal for optimal internal homeostatic regulation.
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